Nitroxoline
Modify Date: 2024-01-02 11:41:23
Nitroxoline structure
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Common Name | Nitroxoline | ||
|---|---|---|---|---|
| CAS Number | 4008-48-4 | Molecular Weight | 190.156 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 419.0±35.0 °C at 760 mmHg | |
| Molecular Formula | C9H6N2O3 | Melting Point | 181-183ºC | |
| MSDS | Chinese USA | Flash Point | 207.2±25.9 °C | |
| Symbol |
GHS06 |
Signal Word | Danger | |
Use of NitroxolineNitroxoline is an antibiotic that has proven to be very effective at combating biofilm infections. Nitroxoline functions by chelating Fe2+ and Zn2+ ions from the biofilm matrix. |
| Name | nitroxoline |
|---|---|
| Synonym | More Synonyms |
| Description | Nitroxoline is an antibiotic that has proven to be very effective at combating biofilm infections. Nitroxoline functions by chelating Fe2+ and Zn2+ ions from the biofilm matrix. |
|---|---|
| Related Catalog |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 419.0±35.0 °C at 760 mmHg |
| Melting Point | 181-183ºC |
| Molecular Formula | C9H6N2O3 |
| Molecular Weight | 190.156 |
| Flash Point | 207.2±25.9 °C |
| Exact Mass | 190.037842 |
| PSA | 78.94000 |
| LogP | 2.00 |
| Vapour Pressure | 0.0±1.0 mmHg at 25°C |
| Index of Refraction | 1.728 |
| Water Solubility | alcohol: very slightly soluble |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
|
| Symbol |
GHS06 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H301 + H311 + H331-H315-H319-H335 |
| Precautionary Statements | P261-P280-P301 + P310-P305 + P351 + P338-P311 |
| Personal Protective Equipment | Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges |
| Hazard Codes | T:Toxic; |
| Risk Phrases | R22/24/25;R36/37/38 |
| Safety Phrases | S26-S36-S45 |
| RIDADR | UN 2811 |
| WGK Germany | 3 |
| RTECS | VC8225000 |
| Packaging Group | III |
| Hazard Class | 6.1 |
| HS Code | 2933499090 |
|
~70%
Nitroxoline CAS#:4008-48-4 |
| Literature: Kidwai, Mazaahir; Kohli, Seema Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1997 , vol. 36, # 11 p. 1071 - 1073 |
|
~%
Nitroxoline CAS#:4008-48-4 |
| Literature: Isaev; Lomovskii; Korolev; Karimov Chemistry of Heterocyclic Compounds, 2005 , vol. 41, # 8 p. 1027 - 1030 |
|
~%
Nitroxoline CAS#:4008-48-4 |
| Literature: Vis Journal fuer Praktische Chemie (Leipzig), 1892 , vol. <2> 45, p. 540 |
|
~%
Nitroxoline CAS#:4008-48-4 |
| Literature: Vogt; Jeske Archiv der Pharmazie (Weinheim, Germany), 1958 , vol. 291, p. 168,175 |
|
~%
Nitroxoline CAS#:4008-48-4 |
| Literature: Broxton; Nasser Canadian Journal of Chemistry, 1997 , vol. 75, # 2 p. 202 - 206 |
|
~%
Nitroxoline CAS#:4008-48-4 |
| Literature: Belov; Nichvoloda Russian Journal of Organic Chemistry, 2004 , vol. 40, # 1 p. 93 - 96 |
|
~%
Nitroxoline CAS#:4008-48-4 |
| Literature: Vis Journal fuer Praktische Chemie (Leipzig), 1892 , vol. <2> 45, p. 540 |
| Precursor 7 | |
|---|---|
| DownStream 10 | |
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CAS#:74440-56-5![7-[(bis(2-hydroxyethyl)amino)methyl]-5-nitro-quinolin-8-ol structure](https://www.chemsrc.com/caspic/033/74440-57-6.png)
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CAS#:75793-53-2![7-[(2-hydroxyethylamino)methyl]-5-nitro-quinolin-8-ol structure](https://www.chemsrc.com/caspic/018/76289-25-3.png)
CAS#:76289-25-3| HS Code | 2933499090 |
|---|---|
| Summary | 2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Development of new cathepsin B inhibitors: combining bioisosteric replacements and structure-based design to explore the structure-activity relationships of nitroxoline derivatives.
J. Med. Chem. 56(2) , 521-33, (2013) Human cathepsin B has many house-keeping functions, such as protein turnover in lysosomes. However, dysregulation of its activity is associated with numerous diseases, including cancers. We present he... |
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Redox-based inactivation of cysteine cathepsins by compounds containing the 4-aminophenol moiety.
PLoS ONE 6(11) , e27197, (2011) Redox cycling compounds have been reported to cause false positive inhibition of proteases in drug discovery studies. This kind of false positives can lead to unusually high hit rates in high-throughp... |
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Experimental and theoretical quantum chemical investigations of 8-hydroxy-5-nitroquinoline.
Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 96 , 506-16, (2012) The FT-IR and FT-Raman spectra of 8-hydroxy-5-nitroquinoline have been recorded in the regions 4000-400 and 4000-100 cm(-1), respectively. The spectra were interpreted in terms of fundamentals modes, ... |
| 5-nitryl-8-hydroxyquinoline |
| EINECS 223-662-4 |
| Nitroxolina |
| 5-Nitro-8-quinolinol |
| Notroxoline |
| Enterocol |
| 5-Nitro-8-hydroxyquinoline |
| MFCD00006791 |
| Nitroxolinum |
| 8-Quinolinol, 5-nitro- |
| 5-Hydroxy-8-nitroquinoline |
| 5-nitroquinolin-8-ol |
| Noxibiol |
| Nitroxolin |
| Urocoli |
| Nitroxoline |
| Uritrol |
| 8-Hydroxy-5-Nitroquinoline |
- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: Nitroxoline
- Price: ￥118.0/5g ￥338.0/25g
- Purity: 97.0%
- Stocking Period: 2 Day
- Contact: Liu jia
- DC Chemicals Limited
- China
- Product Name: Nitroxoline
- Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Tony Cao
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: Nitroxoline
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Ms Wang
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Price: ￥390/100g
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