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4008-48-4

4008-48-4 structure
4008-48-4 structure
Name nitroxoline
Synonyms 5-nitryl-8-hydroxyquinoline
EINECS 223-662-4
Nitroxolina
5-Nitro-8-quinolinol
Notroxoline
Enterocol
5-Nitro-8-hydroxyquinoline
MFCD00006791
Nitroxolinum
8-Quinolinol, 5-nitro-
5-Hydroxy-8-nitroquinoline
5-nitroquinolin-8-ol
Noxibiol
Nitroxolin
Urocoli
Nitroxoline
Uritrol
8-Hydroxy-5-Nitroquinoline
Description Nitroxoline is an antibiotic that has proven to be very effective at combating biofilm infections. Nitroxoline functions by chelating Fe2+ and Zn2+ ions from the biofilm matrix.
Related Catalog
Density 1.5±0.1 g/cm3
Boiling Point 419.0±35.0 °C at 760 mmHg
Melting Point 181-183ºC
Molecular Formula C9H6N2O3
Molecular Weight 190.156
Flash Point 207.2±25.9 °C
Exact Mass 190.037842
PSA 78.94000
LogP 2.00
Vapour Pressure 0.0±1.0 mmHg at 25°C
Index of Refraction 1.728
Water Solubility alcohol: very slightly soluble

CHEMICAL IDENTIFICATION

RTECS NUMBER :
VC8225000
CHEMICAL NAME :
8-Quinolinol, 5-nitro-
CAS REGISTRY NUMBER :
4008-48-4
BEILSTEIN REFERENCE NO. :
0166146
LAST UPDATED :
199712
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C9-H6-N2-O3
MOLECULAR WEIGHT :
190.17
WISWESSER LINE NOTATION :
T66 BNJ GNW JQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
510 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
ATXKA8 Archiv fuer Toxikologie. (Berlin, Fed. Rep. Ger.) V.15-31, 1954-74. For publisher information, see ARTODN. Volume(issue)/page/year: 20,313,1965
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
104 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
ATXKA8 Archiv fuer Toxikologie. (Berlin, Fed. Rep. Ger.) V.15-31, 1954-74. For publisher information, see ARTODN. Volume(issue)/page/year: 20,313,1965
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
8300 ug/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
ATXKA8 Archiv fuer Toxikologie. (Berlin, Fed. Rep. Ger.) V.15-31, 1954-74. For publisher information, see ARTODN. Volume(issue)/page/year: 20,313,1965 ** TUMORIGENIC DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
13 gm/kg/52W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Blood - lymphoma, including Hodgkin's disease
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 8,343,1966
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
26 gm/kg/52W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Blood - lymphoma, including Hodgkin's disease
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 8,343,1966
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
52 gm/kg/52W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Blood - lymphoma, including Hodgkin's disease
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 8,343,1966
Symbol GHS06
GHS06
Signal Word Danger
Hazard Statements H301 + H311 + H331-H315-H319-H335
Precautionary Statements P261-P280-P301 + P310-P305 + P351 + P338-P311
Personal Protective Equipment Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
Hazard Codes T:Toxic;
Risk Phrases R22/24/25;R36/37/38
Safety Phrases S26-S36-S45
RIDADR UN 2811
WGK Germany 3
RTECS VC8225000
Packaging Group III
Hazard Class 6.1
HS Code 2933499090
148-24-3 structure

148-24-3

~70%

4008-48-4 structure

4008-48-4

Literature: Kidwai, Mazaahir; Kohli, Seema Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1997 , vol. 36, # 11 p. 1071 - 1073
3565-26-2 structure

3565-26-2

~%

4008-48-4 structure

4008-48-4

Literature: Isaev; Lomovskii; Korolev; Karimov Chemistry of Heterocyclic Compounds, 2005 , vol. 41, # 8 p. 1027 - 1030
19746-57-7 structure

19746-57-7

~%

4008-48-4 structure

4008-48-4

Literature: Vis Journal fuer Praktische Chemie (Leipzig), 1892 , vol. <2> 45, p. 540
56-81-5 structure

56-81-5

99-57-0 structure

99-57-0

~%

4008-48-4 structure

4008-48-4

Literature: Vogt; Jeske Archiv der Pharmazie (Weinheim, Germany), 1958 , vol. 291, p. 168,175
42322-37-2 structure

42322-37-2

~%

4008-48-4 structure

4008-48-4

Literature: Broxton; Nasser Canadian Journal of Chemistry, 1997 , vol. 75, # 2 p. 202 - 206
63450-86-2 structure

63450-86-2

~%

4008-48-4 structure

4008-48-4

Literature: Belov; Nichvoloda Russian Journal of Organic Chemistry, 2004 , vol. 40, # 1 p. 93 - 96
1555-94-8 structure

1555-94-8

~%

4008-48-4 structure

4008-48-4

Literature: Vis Journal fuer Praktische Chemie (Leipzig), 1892 , vol. <2> 45, p. 540
HS Code 2933499090
Summary 2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
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