Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Nitroxoline
Price: ￥118.0/5g ￥338.0/25g
Purity: 97.0%
Stocking Period: 2 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Nitroxoline
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Nitroxoline
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

4008-48-4

4008-48-4 structure

Name: Nitroxoline
Chemical Name: nitroxoline
CAS Number: 4008-48-4
Molecular Formula: C₉H₆N₂O₃
Molecular Weight: 190.156
Catalog: Pharmaceutical intermediate Heterocyclic compound Quinoline compound
Create Date: 2018-04-29 08:00:00
Modify Date: 2024-01-02 11:41:23
Nitroxoline is an antibiotic that has proven to be very effective at combating biofilm infections. Nitroxoline functions by chelating Fe2+ and Zn2+ ions from the biofilm matrix.

Name	nitroxoline
Synonyms	5-nitryl-8-hydroxyquinoline EINECS 223-662-4 Nitroxolina 5-Nitro-8-quinolinol Notroxoline Enterocol 5-Nitro-8-hydroxyquinoline MFCD00006791 Nitroxolinum 8-Quinolinol, 5-nitro- 5-Hydroxy-8-nitroquinoline 5-nitroquinolin-8-ol Noxibiol Nitroxolin Urocoli Nitroxoline Uritrol 8-Hydroxy-5-Nitroquinoline

Description	Nitroxoline is an antibiotic that has proven to be very effective at combating biofilm infections. Nitroxoline functions by chelating Fe2+ and Zn2+ ions from the biofilm matrix.
Related Catalog	Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection

Density	1.5±0.1 g/cm3
Boiling Point	419.0±35.0 °C at 760 mmHg
Melting Point	181-183ºC
Molecular Formula	C₉H₆N₂O₃
Molecular Weight	190.156
Flash Point	207.2±25.9 °C
Exact Mass	190.037842
PSA	78.94000
LogP	2.00
Vapour Pressure	0.0±1.0 mmHg at 25°C
Index of Refraction	1.728
Water Solubility	alcohol: very slightly soluble

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VC8225000

CHEMICAL NAME :: 8-Quinolinol, 5-nitro-

CAS REGISTRY NUMBER :: 4008-48-4

BEILSTEIN REFERENCE NO. :: 0166146

LAST UPDATED :: 199712

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C9-H6-N2-O3

MOLECULAR WEIGHT :: 190.17

WISWESSER LINE NOTATION :: T66 BNJ GNW JQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 510 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: ATXKA8 Archiv fuer Toxikologie. (Berlin, Fed. Rep. Ger.) V.15-31, 1954-74. For publisher information, see ARTODN. Volume(issue)/page/year: 20,313,1965

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 104 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: ATXKA8 Archiv fuer Toxikologie. (Berlin, Fed. Rep. Ger.) V.15-31, 1954-74. For publisher information, see ARTODN. Volume(issue)/page/year: 20,313,1965

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 8300 ug/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: ATXKA8 Archiv fuer Toxikologie. (Berlin, Fed. Rep. Ger.) V.15-31, 1954-74. For publisher information, see ARTODN. Volume(issue)/page/year: 20,313,1965 ** TUMORIGENIC DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 13 gm/kg/52W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Blood - lymphoma, including Hodgkin's disease

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 8,343,1966

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 26 gm/kg/52W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Blood - lymphoma, including Hodgkin's disease

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 8,343,1966

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 52 gm/kg/52W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Blood - lymphoma, including Hodgkin's disease

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 8,343,1966

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H301 + H311 + H331-H315-H319-H335
Precautionary Statements	P261-P280-P301 + P310-P305 + P351 + P338-P311
Personal Protective Equipment	Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
Hazard Codes	T:Toxic;
Risk Phrases	R22/24/25;R36/37/38
Safety Phrases	S26-S36-S45
RIDADR	UN 2811
WGK Germany	3
RTECS	VC8225000
Packaging Group	III
Hazard Class	6.1
HS Code	2933499090

148-24-3

~70%

4008-48-4

Literature: Kidwai, Mazaahir; Kohli, Seema Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1997 , vol. 36, # 11 p. 1071 - 1073

3565-26-2

4008-48-4

Literature: Isaev; Lomovskii; Korolev; Karimov Chemistry of Heterocyclic Compounds, 2005 , vol. 41, # 8 p. 1027 - 1030

19746-57-7

4008-48-4

Literature: Vis Journal fuer Praktische Chemie (Leipzig), 1892 , vol. <2> 45, p. 540

56-81-5

99-57-0

4008-48-4

Literature: Vogt; Jeske Archiv der Pharmazie (Weinheim, Germany), 1958 , vol. 291, p. 168,175

42322-37-2

4008-48-4

Literature: Broxton; Nasser Canadian Journal of Chemistry, 1997 , vol. 75, # 2 p. 202 - 206

63450-86-2

4008-48-4

Literature: Belov; Nichvoloda Russian Journal of Organic Chemistry, 2004 , vol. 40, # 1 p. 93 - 96

1555-94-8

4008-48-4

Literature: Vis Journal fuer Praktische Chemie (Leipzig), 1892 , vol. <2> 45, p. 540

Precursor 7
148-24-3 3565-26-2 19746-57-7 56-81-5
99-57-0 42322-37-2 1555-94-8
DownStream 10
23521-17-7 23521-16-6 19746-57-7 13207-66-4
17012-47-4 21302-43-2 74440-56-5 74440-57-6
75793-53-2 76289-25-3

HS Code	2933499090
Summary	2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

56-41-7	108-65-6
56-35-9	64-17-5
67-56-1	108-88-3
141-78-6	1310-73-2
13463-67-7	1333-86-4