Benurestat

Modify Date: 2024-01-03 10:42:44

Benurestat Structure
Benurestat structure
Common Name Benurestat
CAS Number 38274-54-3 Molecular Weight 228.63200
Density 1.414g/cm3 Boiling Point N/A
Molecular Formula C9H9ClN2O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Benurestat


Benurestat is an orally active urease inhibitor. Benurestat can be used for infected ureolysis research[1].

 Names

Name 4-chloro-N-[2-(hydroxyamino)-2-oxoethyl]benzamide
Synonym More Synonyms

 Benurestat Biological Activity

Description Benurestat is an orally active urease inhibitor. Benurestat can be used for infected ureolysis research[1].
Related Catalog
In Vivo Benurestat administration, 25 mg/kg, 50 mg/kg, or 100 mg/kg, causes a decrease in the urinary excretion of ammonia from rats with experimental P. mirabilis genitourinary tract infection[1]. The number of viable bacteria present in the bladders of infected rats is significantly less after the administration of Benurestat plus Nitrofurantoin, Sulfamethoxazole, or Ampicillin than the respective numbers that are obtained from control infected rats or from rats administered either component of the combination separately[1].
References

[1]. J A Andersen. Benurestat, a urease inhibitor for the therapy of infected ureolysis. Invest Urol. 1975 Mar;12(5):381-6.

 Chemical & Physical Properties

Density 1.414g/cm3
Molecular Formula C9H9ClN2O3
Molecular Weight 228.63200
Exact Mass 228.03000
PSA 78.43000
LogP 1.35700
Index of Refraction 1.59

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AK8317000
CHEMICAL NAME :
Acetohydroxamic acid, 2-(p-chlorobenzamido)-
CAS REGISTRY NUMBER :
38274-54-3
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C9-H9-Cl-N2-O3
MOLECULAR WEIGHT :
228.65
WISWESSER LINE NOTATION :
QMV1MVR DG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :
DNA repair
TEST SYSTEM :
Bacteria - Bacillus subtilis
DOSE/DURATION :
10 umol/disc
REFERENCE :
JOPHDQ Journal of Pharmacobio-Dynamics. (Japan Pub. Trading Co. (USA), 1255 Howard St., San Francisco, CA 94103) V.1- 1978- Volume(issue)/page/year: 3,557,1980

 Safety Information

Hazard Codes Xi
HS Code 2924299090

 Customs

HS Code 2924299090
Summary 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Synonyms

EU-2826
Benurstat
Benurestat
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