Benurestat

Names

[ CAS No. ]:
38274-54-3

[ Name ]:
Benurestat

[Synonym ]:
EU-2826
Benurstat
Benurestat

Biological Activity

[Description]:

Benurestat is an orally active urease inhibitor. Benurestat can be used for infected ureolysis research[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[In Vivo]

Benurestat administration, 25 mg/kg, 50 mg/kg, or 100 mg/kg, causes a decrease in the urinary excretion of ammonia from rats with experimental P. mirabilis genitourinary tract infection[1]. The number of viable bacteria present in the bladders of infected rats is significantly less after the administration of Benurestat plus Nitrofurantoin, Sulfamethoxazole, or Ampicillin than the respective numbers that are obtained from control infected rats or from rats administered either component of the combination separately[1].

[References]

[1]. J A Andersen. Benurestat, a urease inhibitor for the therapy of infected ureolysis. Invest Urol. 1975 Mar;12(5):381-6.

Chemical & Physical Properties

[ Density]:
1.414g/cm3

[ Molecular Formula ]:
C₉H₉ClN₂O₃

[ Molecular Weight ]:
228.63200

[ Exact Mass ]:
228.03000

[ PSA ]:
78.43000

[ LogP ]:
1.35700

[ Index of Refraction ]:
1.59

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AK8317000

CHEMICAL NAME :: Acetohydroxamic acid, 2-(p-chlorobenzamido)-

CAS REGISTRY NUMBER :: 38274-54-3

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C9-H9-Cl-N2-O3

MOLECULAR WEIGHT :: 228.65

WISWESSER LINE NOTATION :: QMV1MVR DG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: DNA repair

TEST SYSTEM :: Bacteria - Bacillus subtilis

DOSE/DURATION :: 10 umol/disc

REFERENCE :: JOPHDQ Journal of Pharmacobio-Dynamics. (Japan Pub. Trading Co. (USA), 1255 Howard St., San Francisco, CA 94103) V.1- 1978- Volume(issue)/page/year: 3,557,1980

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2924299090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2924299090

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.