21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione

Modify Date: 2025-08-23 20:03:07

21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione structure	Common Name	21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione
	CAS Number	37413-91-5	Molecular Weight	366.450
	Density	1.2±0.1 g/cm3	Boiling Point	534.6±50.0 °C at 760 mmHg
	Molecular Formula	C₂₃H₂₆O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	233.0±30.2 °C

Use of 21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione

21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione is an intermediate of delta 9,11 steroids synthesis, for example, Vamorolone (HY-109017). The delta 9,11 steroids are modifications of glucocorticoids and has anti-inflammatory properties. The delta 9,11 steroids are agents for protection against cell damage (lipid peroxidation) and inhibition of neovascularization[1].

Name	[2-[(8S,10S,13S,14S)-10,13-dimethyl-3-oxo-6,7,8,12,14,15-hexahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate
Synonym	More Synonyms

Description	21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione is an intermediate of delta 9,11 steroids synthesis, for example, Vamorolone (HY-109017). The delta 9,11 steroids are modifications of glucocorticoids and has anti-inflammatory properties. The delta 9,11 steroids are agents for protection against cell damage (lipid peroxidation) and inhibition of neovascularization[1].
Related Catalog	Research Areas >> Inflammation/Immunology Research Areas >> Metabolic Disease Signaling Pathways >> GPCR/G Protein >> Glucocorticoid Receptor
In Vitro	Δ9,11 derivatives are designed and developed to stably incorporate into cell membranes and inhibit lipid peroxidation without glucocorticoid or mineralocorticoid activities, thus avoiding side effects associated with traditional corticosteroids[1]. VBP15 acts as a lead compound due to potent NF-κB inhibition and GR translocation similar to prednisone and dexamethasone, lack of transactivation properties, and good bioavailability[1].
References	[1]. Erica K M Reeves, et al. VBP15: preclinical characterization of a novel anti-inflammatory delta 9,11 steroid. Bioorg Med Chem

Density	1.2±0.1 g/cm3
Boiling Point	534.6±50.0 °C at 760 mmHg
Molecular Formula	C₂₃H₂₆O₄
Molecular Weight	366.450
Flash Point	233.0±30.2 °C
Exact Mass	366.183105
PSA	60.44000
LogP	3.48
Vapour Pressure	0.0±1.4 mmHg at 25°C
Index of Refraction	1.585

2,4,6-Trimethylpyridine structure

2,4,6-Trimethyl...

CAS#:108-75-8

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21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione Structure

21-Acetoxypregn...

CAS#:37413-91-5

Literature: Schaub et al. Journal of the American Chemical Society, 1959 , vol. 81, p. 4962,4966

prednisolone structure

prednisolone

CAS#:50-24-8

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21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione Structure

21-Acetoxypregn...

CAS#:37413-91-5

Literature: Hulcoop, David G.; Shapland, Peter D.P. Steroids, 2013 , vol. 78, # 12-13 p. 1281 - 1287

21-Hydroxypregna-4,9(11),16-triene-3,20-dione 21-acetate structure

21-Hydroxypregn...

CAS#:23460-76-6

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21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione Structure

21-Acetoxypregn...

CAS#:37413-91-5

Literature: Am.Cyanamid Co. Patent: US2864834 , 1957 ;

Precursor 3
CAS#:108-75-8 2,4,6-Trimethyl... CAS#:50-24-8 prednisolone CAS#:23460-76-6 21-Hydroxypregn...
DownStream 1
CAS#:2884-51-7 21-o-acetyl dex...

21-(Acetyloxy)pregna-1,4,9(11),16-tetraene-3,20-dione

EINECS 253-497-3

16-tetraene-3,20-dione 21-acetate

21-hydroxypregna-1,4,9(11)

21-acetoxy-pregna-1,4,9(11),16-tetraene-3,20-dione

3,20-Dioxopregna-1,4,9(11),16-tetraen-21-yl acetate

21-Acetoxy-pregna-1,4,9(11),16-tetraen-3,20-dion

Pregna-1,4,9(11),16-tetraene-3,20-dione, 21-(acetyloxy)-

21-hydroxy-pregna-1,4,9(11),16-tetraene-3,20-dione 21-acetate

2-((8S,10S,13S,14S)-10,13-dimethyl-3-oxo-6,7,8,10,12,13,14,15-octahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate

21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: 21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione
Price: ￥376.0/5g ￥146.0/1g ￥606.0/10g ￥1216.0/25g
Purity: 95.0%
Delivery: 1 Day
Contact: Liu jia
Email: 2130147988@qq.com

DC Chemicals Limited
China
Product Name: 21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione
Price: $Inquiry/250mg $Inquiry/100mg $Inquiry/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 3,20-Dioxopregna-1,4,9(11),16-tetraen-21-yl acetate
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: 3,20-Dioxopregna-1,4,9(11),16-tetraen-21-yl acetate
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

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Price: ￥550/10 mM * 1 mL in DMSO

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