- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: 21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione
- Price: ￥376.0/5g ￥146.0/1g ￥606.0/10g ￥1216.0/25g
- Purity: 95.0%
- Stocking Period: 1 Day
- Contact: Liu jia
- DC Chemicals Limited
- China
- Product Name: 21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione
- Price: $Inquiry/250mg $Inquiry/100mg $Inquiry/1g
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Tony Cao
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: 3,20-Dioxopregna-1,4,9(11),16-tetraen-21-yl acetate
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Ms Wang
- Henan Tianfu Chemical Co., Ltd.
- China
- Product Name: 3,20-Dioxopregna-1,4,9(11),16-tetraen-21-yl acetate
- Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
- Purity: 99.0%
- Stocking Period: Inquiry
- Contact: Anson
37413-91-5
37413-91-5 structure
- Name: 21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione
- Chemical Name: [2-[(8S,10S,13S,14S)-10,13-dimethyl-3-oxo-6,7,8,12,14,15-hexahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate
- CAS Number: 37413-91-5
- Molecular Formula: C23H26O4
- Molecular Weight: 366.450
- Catalog: Signaling Pathways GPCR/G Protein Glucocorticoid Receptor
- Create Date: 2018-08-30 11:11:38
- Modify Date: 2024-01-08 10:54:30
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21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione is an intermediate of delta 9,11 steroids synthesis, for example, Vamorolone (HY-109017). The delta 9,11 steroids are modifications of glucocorticoids and has anti-inflammatory properties. The delta 9,11 steroids are agents for protection against cell damage (lipid peroxidation) and inhibition of neovascularization[1].
| Name | [2-[(8S,10S,13S,14S)-10,13-dimethyl-3-oxo-6,7,8,12,14,15-hexahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate |
|---|---|
| Synonyms |
21-(Acetyloxy)pregna-1,4,9(11),16-tetraene-3,20-dione
EINECS 253-497-3 16-tetraene-3,20-dione 21-acetate 21-hydroxypregna-1,4,9(11) 21-acetoxy-pregna-1,4,9(11),16-tetraene-3,20-dione 3,20-Dioxopregna-1,4,9(11),16-tetraen-21-yl acetate 21-Acetoxy-pregna-1,4,9(11),16-tetraen-3,20-dion Pregna-1,4,9(11),16-tetraene-3,20-dione, 21-(acetyloxy)- 21-hydroxy-pregna-1,4,9(11),16-tetraene-3,20-dione 21-acetate 2-((8S,10S,13S,14S)-10,13-dimethyl-3-oxo-6,7,8,10,12,13,14,15-octahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate 21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione |
| Description | 21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione is an intermediate of delta 9,11 steroids synthesis, for example, Vamorolone (HY-109017). The delta 9,11 steroids are modifications of glucocorticoids and has anti-inflammatory properties. The delta 9,11 steroids are agents for protection against cell damage (lipid peroxidation) and inhibition of neovascularization[1]. |
|---|---|
| Related Catalog | |
| In Vitro | Δ9,11 derivatives are designed and developed to stably incorporate into cell membranes and inhibit lipid peroxidation without glucocorticoid or mineralocorticoid activities, thus avoiding side effects associated with traditional corticosteroids[1]. VBP15 acts as a lead compound due to potent NF-κB inhibition and GR translocation similar to prednisone and dexamethasone, lack of transactivation properties, and good bioavailability[1]. |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 534.6±50.0 °C at 760 mmHg |
| Molecular Formula | C23H26O4 |
| Molecular Weight | 366.450 |
| Flash Point | 233.0±30.2 °C |
| Exact Mass | 366.183105 |
| PSA | 60.44000 |
| LogP | 3.48 |
| Vapour Pressure | 0.0±1.4 mmHg at 25°C |
| Index of Refraction | 1.585 |
|
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37413-91-5 |
| Literature: Schaub et al. Journal of the American Chemical Society, 1959 , vol. 81, p. 4962,4966 |
|
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37413-91-5 |
| Literature: Hulcoop, David G.; Shapland, Peter D.P. Steroids, 2013 , vol. 78, # 12-13 p. 1281 - 1287 |
|
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37413-91-5 |
| Literature: Am.Cyanamid Co. Patent: US2864834 , 1957 ; |
| Precursor 3 | |
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| DownStream 1 | |
