Carnosic acid

Modify Date: 2024-01-02 18:30:59

Carnosic acid Structure
Carnosic acid structure
Common Name Carnosic acid
CAS Number 3650-09-7 Molecular Weight 332.434
Density 1.2±0.1 g/cm3 Boiling Point 506.4±50.0 °C at 760 mmHg
Molecular Formula C20H28O4 Melting Point 190 °C
MSDS Chinese USA Flash Point 274.2±26.6 °C

 Use of Carnosic acid


Carnosic acid has demonstrated inhibition of oxidative stress and inflammation, suppression of cell proliferation, and antibacterial activity.

 Names

Name carnosic acid
Synonym More Synonyms

 Carnosic acid Biological Activity

Description Carnosic acid has demonstrated inhibition of oxidative stress and inflammation, suppression of cell proliferation, and antibacterial activity.
Related Catalog
In Vitro Carnosic acid, a phenolic diterpene, is enriched in the leaves of Lamiaceae plants, and is particularly high in dried leaves of Rosmarinus officinalis L. and Salvia officinalis. Carnosic acid has demonstrated inhibition of oxidative stress and inflammation, suppression of cell proliferation, and antibacterial activity. It is widely reported that Carnosic acid has a therapeutic potential in different types of cancer, mostly based on in vitro experiments. Carnosic acid has also shown neuroprotective effects in experimental models of neurodegenerative diseases, mainly through activation of the antioxidant NRF2/ARE pathway[1].
References

[1]. Yesil-Celiktas O, et al. Inhibitory effects of rosemary extracts, carnosic acid and rosmarinic acid on the growth of various human cancer cell lines. Plant Foods Hum Nutr. 2010 Jun;65(2):158-63.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 506.4±50.0 °C at 760 mmHg
Melting Point 190 °C
Molecular Formula C20H28O4
Molecular Weight 332.434
Flash Point 274.2±26.6 °C
Exact Mass 332.198761
PSA 77.76000
LogP 4.93
Vapour Pressure 0.0±1.4 mmHg at 25°C
Index of Refraction 1.576
Storage condition −20°C

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xn
Safety Phrases S22-S24/25
RIDADR NONH for all modes of transport
WGK Germany 3

 Synthetic Route

~70%

Carnosic acid Structure

Carnosic acid

CAS#:3650-09-7

Literature: Tada, Masahiro; Ohkanda, Tomoyuki; Kurabe, Jun Chemical and Pharmaceutical Bulletin, 2010 , vol. 58, # 1 p. 27 - 29

 Articles18

More Articles
Redox-dependent induction of antioxidant defenses by phenolic diterpenes confers stress tolerance in normal human skin fibroblasts: Insights on replicative senescence.

Free Radic. Biol. Med. 83 , 262-72, (2015)

Mild stress-induced hormesis represents a promising strategy for targeting the age-related accumulation of molecular damage and, therefore, for preventing diseases and achieving healthy aging. Fruits,...

Carnosol Is a Potent Lung Protective Agent: Experimental Study on Mice.

Transplant. Proc. 47 , 1657-61, (2015)

Oxidative stress has been implicated in various disease states and ischemia/reperfusion injury is a direct consequence of oxidative stress in lung transplantation. Because the success rate of organ tr...

Enhanced Eryptosis Following Exposure to Carnosic Acid.

Cell Physiol. Biochem. 37 , 1779-91, (2015)

The phenolic abietane diterpene component of rosemary and sage, carnosic acid, may either induce or inhibit apoptosis of nucleated cells. The mechanisms involved in the effects of carnosic acid includ...

 Synonyms

Salvin
4a(2H)-Phenanthrenecarboxylic acid, 1,3,4,9,10,10a-hexahydro-5,6-dihydroxy-1,1-dimethyl-7-(1-methylethyl)-, (4aR,10aS)-
Carnosic acid
RoseOx
11,12-Dihydroxyabieta-8,11,13-trien-20-oic acid
Carnosic acid
(4aR,10aS)-5,6-dihydroxy-1,1-dimethyl-7-propan-2-yl-2,3,4,9,10,10a-hexahydrophenanthrene-4a-carboxylic acid
MFCD02259459
Carsonic acid
Carnosolic Acid
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  • BioBioPha
  • China
  • Product Name: Carnosic acid
  • Price: ¥Inquiry/50mg
  • Purity: 98.0%
  • Stocking Period: 1 Day
  • Contact: Xueping-Zheng





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Price: ¥312/10mg

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