Amiprofos methyl

Modify Date: 2024-01-16 13:57:09

Amiprofos methyl structure	Common Name	Amiprofos methyl
	CAS Number	36001-88-4	Molecular Weight	304.30
	Density	1.275g/cm3	Boiling Point	389.9ºC at 760mmHg
	Molecular Formula	C₁₁H₁₇N₂O₄PS	Melting Point	-65ºC
	MSDS	Chinese USA	Flash Point	189.6ºC
	Symbol	GHS07	Signal Word	Warning

Use of Amiprofos methyl

Amiprofos methyl (BAY-NTN 6867) is a phosphoric amide herbicide. Amiprofos methyl is a specific and potent antimicrotubule agent. Amiprofos methyl directly poisons microtubule dynamics in plant cells[1].

Name	amiprofos-methyl
Synonym	More Synonyms

Description	Amiprofos methyl (BAY-NTN 6867) is a phosphoric amide herbicide. Amiprofos methyl is a specific and potent antimicrotubule agent. Amiprofos methyl directly poisons microtubule dynamics in plant cells[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin
In Vitro	Amiprofos methyl (APM) inhibits competitively the binding of [14C]oryzalin to tubulin with a Ki=5 μM. Amiprofos methyl concentrations inhibiting tobacco cell growth were within the threshold range of Amiprofos methyl concentrations that depolymerized cellular microtubules, indicating that growth inhibition is caused by microtubules depolymerization[2].
References	[1]. Morejohn LC, et al. Inhibition of Plant Microtubule Polymerization in vitro by the Phosphoric Amide Herbicide Amiprophos-Methyl. Science. 1984;224(4651):874-876. [2]. Murthy JV, et al. Competitive Inhibition of High-Affinity Oryzalin Binding to Plant Tubulin by the Phosphoric Amide Herbicide Amiprophos-Methyl. Plant Physiol. 1994;105(1):309-320.

Density	1.275g/cm3
Boiling Point	389.9ºC at 760mmHg
Melting Point	-65ºC
Molecular Formula	C₁₁H₁₇N₂O₄PS
Molecular Weight	304.30
Flash Point	189.6ºC
Exact Mass	304.06500
PSA	118.21000
LogP	4.71560
Index of Refraction	1.553

Amiprofos methyl MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TB5100000

CHEMICAL NAME :: Phosphoramidothioic acid, N-isopropyl-, O-methyl O-(2-nitro-p-tolyl) ester

CAS REGISTRY NUMBER :: 36001-88-4

LAST UPDATED :: 199710

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C11-H17-N2-O4-P-S

MOLECULAR WEIGHT :: 304.33

WISWESSER LINE NOTATION :: WNR C1 FOPS&O1&MY1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 309 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85ARAE "Agricultural Chemicals," Thomson, W.T., 4 vols., Fresno, CA, Thomson Publications, 1976/77 revision Volume(issue)/page/year: 2,212,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: SHBOAO Shokubutsu Boeki. (Nippon Shokubutsu Boeki Kyokai, 43-11, Komagome 1-chome, Toshima-Ku, Tokyo, Japan) V.1- 1947- Volume(issue)/page/year: 32,488,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 540 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: SHBOAO Shokubutsu Boeki. (Nippon Shokubutsu Boeki Kyokai, 43-11, Komagome 1-chome, Toshima-Ku, Tokyo, Japan) V.1- 1947- Volume(issue)/page/year: 32,488,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >4 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: SHBOAO Shokubutsu Boeki. (Nippon Shokubutsu Boeki Kyokai, 43-11, Komagome 1-chome, Toshima-Ku, Tokyo, Japan) V.1- 1947- Volume(issue)/page/year: 32,488,1978

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes	Xn: Harmful;
Risk Phrases	R22
Safety Phrases	36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	TB5100000
HS Code	2929909011

HS Code	2929909011
Summary	2929909011 o-methyl o-(4-methyl-2-nitrophenyl) isopropylphosphoramidothioate

Blockage of mitosis in maize root tips using colchicine-alternatives.

Protoplasma 241(1-4) , 99-104, (2010)

Mitosis in plants can be blocked by colchicine which has the capacity to bind microtubule subunits. In maize (Zea mays L.) breeding, it is frequently being used for doubling chromosome numbers of hapl...

In vivo dynamics and differential microtubule-binding activities of MAP65 proteins.

Plant Physiol. 136(4) , 3956-67, (2004)

Plant cells produce different microtubule arrays that are essential for cell division and morphogenesis without equivalent in other eukaryotes. Microtubule-associated proteins influence the behavior o...

Microtubule distribution in gravitropic protonemata of the moss Ceratodon.

Protoplasma 159 , 60-9, (1990)

Tip cells of dark-grown protonemata of the moss Ceratodon purpureus are negatively gravitropic (grow upward). They possess a unique longitudinal zonation: (1) a tip group of amylochloroplasts in the a...

O-methyl O-(4-methyl-2-nitrophenyl) N-(1-methylethyl)phosphoramidothioate

Amiprofos methyl

(RS)-(O-methyl O-2-nitro-p-tolyl isopropylphosphoramidothioate)

(Ξ)-[O-methyl O-(4-methyl-2-nitrophenyl) propan-2-ylphosphoramidothioate]

O-Methyl O-(2-nitro-p-tolyl) N-isopropylphosphoramidothionate

N-[methoxy-(4-methyl-2-nitrophenoxy)phosphinothioyl]propan-2-amine

amiprophos-methyl

DC Chemicals Limited
China
Product Name: Amiprofos methyl
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Phosphoramidothioicacid, N-(1-methylethyl)-, O-methyl O-(4-methyl-2-nitrophenyl) ester
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Get all suppliers and price by the below link:

Amiprofos methyl suppliers

Amiprofos methyl price

Amiprofos methyl

Use of Amiprofos methyl

Names