36001-88-4

36001-88-4 structure

Name: Amiprofos methyl
Chemical Name: amiprofos-methyl
CAS Number: 36001-88-4
Molecular Formula: C₁₁H₁₇N₂O₄PS
Molecular Weight: 304.30
Catalog: analytical chemistry Standard Pesticides, veterinary drugs and fertilizers
Create Date: 2018-06-25 11:30:31
Modify Date: 2025-08-23 18:51:56
Amiprofos methyl (BAY-NTN 6867) is a phosphoric amide herbicide. Amiprofos methyl is a specific and potent antimicrotubule agent. Amiprofos methyl directly poisons microtubule dynamics in plant cells[1].

Name	amiprofos-methyl
Synonyms	O-methyl O-(4-methyl-2-nitrophenyl) N-(1-methylethyl)phosphoramidothioate Amiprofos methyl (RS)-(O-methyl O-2-nitro-p-tolyl isopropylphosphoramidothioate) (Ξ)-[O-methyl O-(4-methyl-2-nitrophenyl) propan-2-ylphosphoramidothioate] O-Methyl O-(2-nitro-p-tolyl) N-isopropylphosphoramidothionate N-[methoxy-(4-methyl-2-nitrophenoxy)phosphinothioyl]propan-2-amine amiprophos-methyl

Description	Amiprofos methyl (BAY-NTN 6867) is a phosphoric amide herbicide. Amiprofos methyl is a specific and potent antimicrotubule agent. Amiprofos methyl directly poisons microtubule dynamics in plant cells[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin
In Vitro	Amiprofos methyl (APM) inhibits competitively the binding of [14C]oryzalin to tubulin with a Ki=5 μM. Amiprofos methyl concentrations inhibiting tobacco cell growth were within the threshold range of Amiprofos methyl concentrations that depolymerized cellular microtubules, indicating that growth inhibition is caused by microtubules depolymerization[2].
References	[1]. Morejohn LC, et al. Inhibition of Plant Microtubule Polymerization in vitro by the Phosphoric Amide Herbicide Amiprophos-Methyl. Science. 1984;224(4651):874-876. [2]. Murthy JV, et al. Competitive Inhibition of High-Affinity Oryzalin Binding to Plant Tubulin by the Phosphoric Amide Herbicide Amiprophos-Methyl. Plant Physiol. 1994;105(1):309-320.

CHEMICAL NAME :: Phosphoramidothioic acid, N-isopropyl-, O-methyl O-(2-nitro-p-tolyl) ester

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85ARAE "Agricultural Chemicals," Thomson, W.T., 4 vols., Fresno, CA, Thomson Publications, 1976/77 revision Volume(issue)/page/year: 2,212,1977

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: SHBOAO Shokubutsu Boeki. (Nippon Shokubutsu Boeki Kyokai, 43-11, Komagome 1-chome, Toshima-Ku, Tokyo, Japan) V.1- 1947- Volume(issue)/page/year: 32,488,1978

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: SHBOAO Shokubutsu Boeki. (Nippon Shokubutsu Boeki Kyokai, 43-11, Komagome 1-chome, Toshima-Ku, Tokyo, Japan) V.1- 1947- Volume(issue)/page/year: 32,488,1978

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: SHBOAO Shokubutsu Boeki. (Nippon Shokubutsu Boeki Kyokai, 43-11, Komagome 1-chome, Toshima-Ku, Tokyo, Japan) V.1- 1947- Volume(issue)/page/year: 32,488,1978

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes	Xn: Harmful;
Risk Phrases	R22
Safety Phrases	36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	TB5100000
HS Code	2929909011

HS Code	2929909011
Summary	2929909011 o-methyl o-(4-methyl-2-nitrophenyl) isopropylphosphoramidothioate