1-[(2R,4S,5R)-5-(aminomethyl)-4-hydroxy-oxolan-2-yl]pyrimidine-2,4-dione

Modify Date: 2024-01-08 17:23:44

1-[(2R,4S,5R)-5-(aminomethyl)-4-hydroxy-oxolan-2-yl]pyrimidine-2,4-dione Structure
1-[(2R,4S,5R)-5-(aminomethyl)-4-hydroxy-oxolan-2-yl]pyrimidine-2,4-dione structure
 Common Name 1-[(2R,4S,5R)-5-(aminomethyl)-4-hydroxy-oxolan-2-yl]pyrimidine-2,4-dione
CAS Number 35959-38-7 Molecular Weight 227.22
Density 1.466g/cm3 Boiling Point N/A
Molecular Formula C9H13N3O4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of 1-[(2R,4S,5R)-5-(aminomethyl)-4-hydroxy-oxolan-2-yl]pyrimidine-2,4-dione


5′-Amino-2′,5′-dideoxyuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

 Names

Name 1-[(2R,4S,5R)-5-(aminomethyl)-4-hydroxyoxolan-2-yl]pyrimidine-2,4-dione
Synonym More Synonyms

  Biological Activity

Description 5′-Amino-2′,5′-dideoxyuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Related Catalog
References

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

 Chemical & Physical Properties

Density 1.466g/cm3
Molecular Formula C9H13N3O4
Molecular Weight 227.22
Exact Mass 227.09100
PSA 110.34000
Index of Refraction 1.601

 Synthetic Route

5’-Azido-2’,5’-dideoxyuridine structure

5’-Azido-2’,5’-...

CAS#:35959-37-6

~96%

1-[(2R,4S,5R)-5-(aminomethyl)-4-hydroxy-oxolan-2-yl]pyrimidine-2,4-dione Structure

1-[(2R,4S,5R)-5...

CAS#:35959-38-7

Literature: Ruda, Gian Filippo; Nguyen, Corinne; Ziemkowski, Przemyslaw; Felczak, Krzysztof; Kasinathan, Ganasan; Musso-Buendia, Alexander; Sund, Christian; Zhou, Xiao Xiong; Kaiser, Marcel; Ruiz-Perez, Luis M.; Brun, Reto; Kulikowski, Tadeusz; Johansson, Nils Gunnar; Gonzalez-Pacanowska, Dolores; Gilbert, Ian H. ChemMedChem, 2011 , vol. 6, # 2 p. 309 - 320
2'-deoxyuridine structure

2'-deoxyuridine

CAS#:951-78-0

~%

1-[(2R,4S,5R)-5-(aminomethyl)-4-hydroxy-oxolan-2-yl]pyrimidine-2,4-dione Structure

1-[(2R,4S,5R)-5...

CAS#:35959-38-7

Literature: Chi, Xiuling; Pahari, Pallab; Nonaka, Koichi; Van Lanen, Steven G. Journal of the American Chemical Society, 2011 , vol. 133, # 36 p. 14452 - 14459
5'-o-(dimethoxytrityl)-5-(propargyloxy)-2'-deoxyuridine structure

5'-o-(dimethoxy...

CAS#:27999-47-9

~%

1-[(2R,4S,5R)-5-(aminomethyl)-4-hydroxy-oxolan-2-yl]pyrimidine-2,4-dione Structure

1-[(2R,4S,5R)-5...

CAS#:35959-38-7

Literature: Ruda, Gian Filippo; Nguyen, Corinne; Ziemkowski, Przemyslaw; Felczak, Krzysztof; Kasinathan, Ganasan; Musso-Buendia, Alexander; Sund, Christian; Zhou, Xiao Xiong; Kaiser, Marcel; Ruiz-Perez, Luis M.; Brun, Reto; Kulikowski, Tadeusz; Johansson, Nils Gunnar; Gonzalez-Pacanowska, Dolores; Gilbert, Ian H. ChemMedChem, 2011 , vol. 6, # 2 p. 309 - 320
Aqueous ammonia structure

Aqueous ammonia

CAS#:1336-21-6

5’-Azido-2’,5’-dideoxyuridine structure

5’-Azido-2’,5’-...

CAS#:35959-37-6

~%

1-[(2R,4S,5R)-5-(aminomethyl)-4-hydroxy-oxolan-2-yl]pyrimidine-2,4-dione Structure

1-[(2R,4S,5R)-5...

CAS#:35959-38-7

Literature: Research Corporation Patent: US4000260 A1, 1976 ;

 Synonyms

5'-Amino-2',5'-dideoxyuridin
5'-Amino-2'-deoxyuridine
5'-NH2-2'-dU
Uridine,5'-amino-2',5'-dideoxy
5'-amino-2',5'-dideoxyuridine
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1-[(2R,4S,5R)-5-(aminomethyl)-4-hydroxy-oxolan-2-yl]pyrimidine-2,4-dione suppliers

1-[(2R,4S,5R)-5-(aminomethyl)-4-hydroxy-oxolan-2-yl]pyrimidine-2,4-dione price

Related Compounds: More...
[6-[[(1S)-1-[(2S,4R)-4-hydroxy-2-[[4-(4-methylthiazol-5-yl)phenyl]methylcarbamoyl]pyrrolidine-1-carbonyl]-2,2-dimethyl-propyl]amino]-6-oxo-hexyl] butanoate
2683008-23-1
(2R,4S)-1-[(2R)-2-[[2-(2-hex-5-enoxyethoxy)acetyl]amino]-3,3-dimethyl-butanoyl]-4-hydroxy-N-[[4-(4-methylthiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide
2306193-49-5
9-[[(1S)-1-[(2S,4R)-4-hydroxy-2-[[(1S)-1-[4-(4-methylthiazol-5-yl)phenyl]ethyl]carbamoyl]pyrrolidine-1-carbonyl]-2,2-dimethyl-propyl]amino]-9-oxo-nonanoic acid
2380273-44-7
4-(azidomethyl)-4H,5H,6H,7H-thieno[3,2-c]pyridine
2021783-95-7
methyl 8-[[(1S)-1-[(2S,4R)-4-hydroxy-2-[[(1S)-1-[4-(4-methylthiazol-5-yl)phenyl]ethyl]carbamoyl]pyrrolidine-1-carbonyl]-2,2-dimethyl-propyl]amino]-8-oxo-octanoate
2471968-10-0
ethyl 8-[[(1S)-1-[(2S,4R)-4-hydroxy-2-[[4-(4-methylthiazol-5-yl)phenyl]methylcarbamoyl]pyrrolidine-1-carbonyl]-2,2-dimethyl-propyl]amino]-8-oxo-octanoate
2380273-57-2
3-[[4-[[(1S)-1-[(2S,4R)-4-hydroxy-2-[[(1S)-1-[4-(4-methylthiazol-5-yl)phenyl]ethyl]carbamoyl]pyrrolidine-1-carbonyl]-2,2-dimethyl-propyl]amino]-4-oxo-butyl]amino]-3-oxo-propanoic acid
2794988-76-2
(2S,4R)-1-[(2S)-2-[[2-[3-(2-azidoethoxy)propoxy]acetyl]amino]-3,3-dimethyl-butanoyl]-4-hydroxy-N-[[4-(4-methylthiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide
2683008-58-2
(2S,4R)-4-hydroxy-1-[(2S)-2-[6-[(2-methoxyacetyl)amino]hexanoylamino]-3,3-dimethyl-butanoyl]-N-[[4-(4-methylthiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide
2683008-15-1
2-[2-[2-[[(1R)-1-[(2R,4S)-4-hydroxy-2-[[(1S)-1-[4-(4-methylthiazol-5-yl)phenyl]ethyl]carbamoyl]pyrrolidine-1-carbonyl]-2,2-dimethyl-propyl]amino]-2-oxo-ethoxy]ethoxy]ethylimino-imino-ammonium
2590653-30-6
Chemsrc provides CAS#:35959-38-7 MSDS, density, melting point, boiling point, structure, etc. Its name is 1-[(2R,4S,5R)-5-(aminomethyl)-4-hydroxy-oxolan-2-yl]pyrimidine-2,4-dione>> amp version: 1-[(2R,4S,5R)-5-(aminomethyl)-4-hydroxy-oxolan-2-yl]pyrimidine-2,4-dione

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