1-[(2R,4S,5R)-5-(aminomethyl)-4-hydroxy-oxolan-2-yl]pyrimidine-2,4-dione

Modify Date: 2025-08-21 18:18:10

1-[(2R,4S,5R)-5-(aminomethyl)-4-hydroxy-oxolan-2-yl]pyrimidine-2,4-dione Structure
1-[(2R,4S,5R)-5-(aminomethyl)-4-hydroxy-oxolan-2-yl]pyrimidine-2,4-dione structure
 Common Name 1-[(2R,4S,5R)-5-(aminomethyl)-4-hydroxy-oxolan-2-yl]pyrimidine-2,4-dione
CAS Number 35959-38-7 Molecular Weight 227.22
Density 1.466g/cm3 Boiling Point N/A
Molecular Formula C9H13N3O4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of 1-[(2R,4S,5R)-5-(aminomethyl)-4-hydroxy-oxolan-2-yl]pyrimidine-2,4-dione


5′-Amino-2′,5′-dideoxyuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

 Names

Name 1-[(2R,4S,5R)-5-(aminomethyl)-4-hydroxyoxolan-2-yl]pyrimidine-2,4-dione
Synonym More Synonyms

  Biological Activity

Description 5′-Amino-2′,5′-dideoxyuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Related Catalog
References

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

 Chemical & Physical Properties

Density 1.466g/cm3
Molecular Formula C9H13N3O4
Molecular Weight 227.22
Exact Mass 227.09100
PSA 110.34000
Index of Refraction 1.601

 Synthetic Route

5’-Azido-2’,5’-dideoxyuridine structure

5’-Azido-2’,5’-...

CAS#:35959-37-6

~96%

1-[(2R,4S,5R)-5-(aminomethyl)-4-hydroxy-oxolan-2-yl]pyrimidine-2,4-dione Structure

1-[(2R,4S,5R)-5...

CAS#:35959-38-7

Literature: Ruda, Gian Filippo; Nguyen, Corinne; Ziemkowski, Przemyslaw; Felczak, Krzysztof; Kasinathan, Ganasan; Musso-Buendia, Alexander; Sund, Christian; Zhou, Xiao Xiong; Kaiser, Marcel; Ruiz-Perez, Luis M.; Brun, Reto; Kulikowski, Tadeusz; Johansson, Nils Gunnar; Gonzalez-Pacanowska, Dolores; Gilbert, Ian H. ChemMedChem, 2011 , vol. 6, # 2 p. 309 - 320
2'-deoxyuridine structure

2'-deoxyuridine

CAS#:951-78-0

~%

1-[(2R,4S,5R)-5-(aminomethyl)-4-hydroxy-oxolan-2-yl]pyrimidine-2,4-dione Structure

1-[(2R,4S,5R)-5...

CAS#:35959-38-7

Literature: Chi, Xiuling; Pahari, Pallab; Nonaka, Koichi; Van Lanen, Steven G. Journal of the American Chemical Society, 2011 , vol. 133, # 36 p. 14452 - 14459
5'-o-(dimethoxytrityl)-5-(propargyloxy)-2'-deoxyuridine structure

5'-o-(dimethoxy...

CAS#:27999-47-9

~%

1-[(2R,4S,5R)-5-(aminomethyl)-4-hydroxy-oxolan-2-yl]pyrimidine-2,4-dione Structure

1-[(2R,4S,5R)-5...

CAS#:35959-38-7

Literature: Ruda, Gian Filippo; Nguyen, Corinne; Ziemkowski, Przemyslaw; Felczak, Krzysztof; Kasinathan, Ganasan; Musso-Buendia, Alexander; Sund, Christian; Zhou, Xiao Xiong; Kaiser, Marcel; Ruiz-Perez, Luis M.; Brun, Reto; Kulikowski, Tadeusz; Johansson, Nils Gunnar; Gonzalez-Pacanowska, Dolores; Gilbert, Ian H. ChemMedChem, 2011 , vol. 6, # 2 p. 309 - 320
Aqueous ammonia structure

Aqueous ammonia

CAS#:1336-21-6

5’-Azido-2’,5’-dideoxyuridine structure

5’-Azido-2’,5’-...

CAS#:35959-37-6

~%

1-[(2R,4S,5R)-5-(aminomethyl)-4-hydroxy-oxolan-2-yl]pyrimidine-2,4-dione Structure

1-[(2R,4S,5R)-5...

CAS#:35959-38-7

Literature: Research Corporation Patent: US4000260 A1, 1976 ;

 Synonyms

5'-Amino-2',5'-dideoxyuridin
5'-Amino-2'-deoxyuridine
5'-NH2-2'-dU
Uridine,5'-amino-2',5'-dideoxy
5'-amino-2',5'-dideoxyuridine
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Chemsrc provides CAS#:35959-38-7 MSDS, density, melting point, boiling point, structure, etc. Its name is 1-[(2R,4S,5R)-5-(aminomethyl)-4-hydroxy-oxolan-2-yl]pyrimidine-2,4-dione>> amp version: 1-[(2R,4S,5R)-5-(aminomethyl)-4-hydroxy-oxolan-2-yl]pyrimidine-2,4-dione

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