35959-38-7
35959-38-7 structure
- Name: 1-[(2R,4S,5R)-5-(aminomethyl)-4-hydroxy-oxolan-2-yl]pyrimidine-2,4-dione
- Chemical Name: 1-[(2R,4S,5R)-5-(aminomethyl)-4-hydroxyoxolan-2-yl]pyrimidine-2,4-dione
- CAS Number: 35959-38-7
- Molecular Formula: C9H13N3O4
- Molecular Weight: 227.22
- Catalog: Signaling Pathways Cell Cycle/DNA Damage Nucleoside Antimetabolite/Analog
- Create Date: 2017-06-17 02:13:31
- Modify Date: 2024-01-08 17:23:44
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5′-Amino-2′,5′-dideoxyuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
| Name | 1-[(2R,4S,5R)-5-(aminomethyl)-4-hydroxyoxolan-2-yl]pyrimidine-2,4-dione |
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| Synonyms |
5'-Amino-2',5'-dideoxyuridin
5'-Amino-2'-deoxyuridine 5'-NH2-2'-dU Uridine,5'-amino-2',5'-dideoxy 5'-amino-2',5'-dideoxyuridine |
| Description | 5′-Amino-2′,5′-dideoxyuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. |
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| Related Catalog | |
| References |
| Density | 1.466g/cm3 |
|---|---|
| Molecular Formula | C9H13N3O4 |
| Molecular Weight | 227.22 |
| Exact Mass | 227.09100 |
| PSA | 110.34000 |
| Index of Refraction | 1.601 |
|
~96%
35959-38-7 |
| Literature: Ruda, Gian Filippo; Nguyen, Corinne; Ziemkowski, Przemyslaw; Felczak, Krzysztof; Kasinathan, Ganasan; Musso-Buendia, Alexander; Sund, Christian; Zhou, Xiao Xiong; Kaiser, Marcel; Ruiz-Perez, Luis M.; Brun, Reto; Kulikowski, Tadeusz; Johansson, Nils Gunnar; Gonzalez-Pacanowska, Dolores; Gilbert, Ian H. ChemMedChem, 2011 , vol. 6, # 2 p. 309 - 320 |
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~%
35959-38-7 |
| Literature: Chi, Xiuling; Pahari, Pallab; Nonaka, Koichi; Van Lanen, Steven G. Journal of the American Chemical Society, 2011 , vol. 133, # 36 p. 14452 - 14459 |
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~%
35959-38-7 |
| Literature: Ruda, Gian Filippo; Nguyen, Corinne; Ziemkowski, Przemyslaw; Felczak, Krzysztof; Kasinathan, Ganasan; Musso-Buendia, Alexander; Sund, Christian; Zhou, Xiao Xiong; Kaiser, Marcel; Ruiz-Perez, Luis M.; Brun, Reto; Kulikowski, Tadeusz; Johansson, Nils Gunnar; Gonzalez-Pacanowska, Dolores; Gilbert, Ian H. ChemMedChem, 2011 , vol. 6, # 2 p. 309 - 320 |
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~%
35959-38-7 |
| Literature: Research Corporation Patent: US4000260 A1, 1976 ; |
| Precursor 4 | |
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| DownStream 3 | |
![2-bromo-N-[[(2R,3S,5R)-5-(5-bromo-2,4-dioxopyrimidin-1-yl)-3-hydroxyoxolan-2-yl]methyl]acetamide structure](https://www.chemsrc.com/caspic/345/106929-03-7.png)
