D-NMAPPD

Modify Date: 2024-01-10 16:43:23

D-NMAPPD Structure
D-NMAPPD structure
Common Name D-NMAPPD
CAS Number 35922-06-6 Molecular Weight 422.558
Density 1.1±0.1 g/cm3 Boiling Point 636.2±55.0 °C at 760 mmHg
Molecular Formula C23H38N2O5 Melting Point N/A
MSDS N/A Flash Point 338.6±31.5 °C

 Use of D-NMAPPD


D-NMAPPD ((1R,2R)-B13) is an acid ceramidase inhibitor. D-NMAPPD regulates NMDA receptor properties by enhancing endogenous production of ceramides. D-NMAPPD has anticancer effecs[1][2].

 Names

Name (1r,2r)-b13
Synonym More Synonyms

 D-NMAPPD Biological Activity

Description D-NMAPPD ((1R,2R)-B13) is an acid ceramidase inhibitor. D-NMAPPD regulates NMDA receptor properties by enhancing endogenous production of ceramides. D-NMAPPD has anticancer effecs[1][2].
Related Catalog
In Vitro In rat hippocampal slices, D-NMAPPD exhibit increased N-methyl-D-aspartate (NMDA) receptor-mediated field excitatory postsynaptic potentials (fEPSPs) in CA1 synapses[1].
References

[1]. Marie-Elaine Laurier-Laurin, et al.Blockade of lysosomal acid ceramidase induces GluN2B-dependent Tau phosphorylation in rat hippocampal slices. Neural Plast. 2014;2014:196812.

[2]. M Selzner, et al.Induction of apoptotic cell death and prevention of tumor growth by ceramide analogues in metastatic human colon cancer. Cancer Res. 2001 Feb 1;61(3):1233-40.

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 636.2±55.0 °C at 760 mmHg
Molecular Formula C23H38N2O5
Molecular Weight 422.558
Flash Point 338.6±31.5 °C
Exact Mass 422.278076
PSA 115.38000
LogP 6.45
Vapour Pressure 0.0±2.0 mmHg at 25°C
Index of Refraction 1.530

 Synonyms

N-[(1R,2R)-1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl]tetradecanamide
d-nmappd
N-[(1R,2R)-1,3-Dihydroxy-1-(4-nitrophenyl)-2-propanyl]tetradecanamide
Tetradecanamide, N-[(1R,2R)-2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]-
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