35922-06-6

35922-06-6 structure

Name: D-NMAPPD
Chemical Name: (1r,2r)-b13
CAS Number: 35922-06-6
Molecular Formula: C₂₃H₃₈N₂O₅
Molecular Weight: 422.558
Catalog: Research Areas Cancer
Create Date: 2017-10-31 22:20:42
Modify Date: 2024-01-10 16:43:23
D-NMAPPD ((1R,2R)-B13) is an acid ceramidase inhibitor. D-NMAPPD regulates NMDA receptor properties by enhancing endogenous production of ceramides. D-NMAPPD has anticancer effecs[1][2].

Name	(1r,2r)-b13
Synonyms	N-[(1R,2R)-1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl]tetradecanamide d-nmappd N-[(1R,2R)-1,3-Dihydroxy-1-(4-nitrophenyl)-2-propanyl]tetradecanamide Tetradecanamide, N-[(1R,2R)-2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]-

Description	D-NMAPPD ((1R,2R)-B13) is an acid ceramidase inhibitor. D-NMAPPD regulates NMDA receptor properties by enhancing endogenous production of ceramides. D-NMAPPD has anticancer effecs[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
In Vitro	In rat hippocampal slices, D-NMAPPD exhibit increased N-methyl-D-aspartate (NMDA) receptor-mediated field excitatory postsynaptic potentials (fEPSPs) in CA1 synapses[1].
References	[1]. Marie-Elaine Laurier-Laurin, et al.Blockade of lysosomal acid ceramidase induces GluN2B-dependent Tau phosphorylation in rat hippocampal slices. Neural Plast. 2014;2014:196812. [2]. M Selzner, et al.Induction of apoptotic cell death and prevention of tumor growth by ceramide analogues in metastatic human colon cancer. Cancer Res. 2001 Feb 1;61(3):1233-40.