Necrostatin-5

Modify Date: 2025-08-26 16:29:24

Necrostatin-5 structure	Common Name	Necrostatin-5
	CAS Number	337349-54-9	Molecular Weight	383.49
	Density	1.4±0.1 g/cm3	Boiling Point	640.4±65.0 °C at 760 mmHg
	Molecular Formula	C₁₉H₁₇N₃O₂S₂	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	341.1±34.3 °C
	Symbol	GHS07	Signal Word	Warning

Use of Necrostatin-5

Necrostatin-5 (Nec-5) is a potent necroptosis inhibitor with an EC50 value of 0.24 µM. Necrostatin-5 also is a RIP1 inhibitor. Necrostatin-5 shows cardioprotective effects[1][2][3].

Name	2-[[3-(4-methoxyphenyl)-4-oxo-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-2-yl]sulfanyl]acetonitrile
Synonym	More Synonyms

Description	Necrostatin-5 (Nec-5) is a potent necroptosis inhibitor with an EC50 value of 0.24 µM. Necrostatin-5 also is a RIP1 inhibitor. Necrostatin-5 shows cardioprotective effects[1][2][3].
Related Catalog	Signaling Pathways >> Apoptosis >> RIP kinase Research Areas >> Neurological Disease
Target	RIPK1 necroptosis:0.24 μM (EC50)
In Vitro	Necrostatin-5 (1、5、10、50、100 µM) 以剂量依赖性方式抑制 LDH 释放[3]。 Necrostatin-5 (100 µM) 保护 MH-S 细胞免受 S. aureus, Listeria monocytogenes, S. pneumoniae, uropathogenic Escherichia coli (UPEC) 的攻击，并防止肺炎球菌溶血素引起的死亡[3]。
In Vivo	Necrostatin-5 (2.46 mg/kg；腹腔注射) 对大鼠离体心脏模型显示心脏保护作用[2]。 Animal Model: 200-300 g, male Wistar rats[2] Dosage: 2.46 mg/kg Administration: I.p.; 60 min before experiment Result: Reduced the infarction zone caused by 30-min global ischemia and 120-min reperfusion.
References	[1]. Wang K, et al. Structure-activity relationship analysis of a novel necroptosis inhibitor, Necrostatin-5. Bioorg Med Chem Lett. 2007 Mar 1;17(5):1455-65. [2]. Dmitriev YV, et al. Study of cardioprotective effects of necroptosis inhibitors on isolated rat heart subjected to global ischemia-reperfusion. Bull Exp Biol Med. 2013 Jun;155(2):245-8. [3]. González-Juarbe N, et al. Pore-Forming Toxins Induce Macrophage Necroptosis during Acute Bacterial Pneumonia. PLoS Pathog. 2015 Dec 11;11(12):e1005337.

Density	1.4±0.1 g/cm3
Boiling Point	640.4±65.0 °C at 760 mmHg
Molecular Formula	C₁₉H₁₇N₃O₂S₂
Molecular Weight	383.49
Flash Point	341.1±34.3 °C
Exact Mass	383.076202
PSA	121.45000
LogP	4.01
Vapour Pressure	0.0±1.9 mmHg at 25°C
Index of Refraction	1.724
InChIKey	VGONMECBFMCKBS-UHFFFAOYSA-N
SMILES	COc1ccc(-n2c(SCC#N)nc3sc4c(c3c2=O)CCCC4)cc1
Storage condition	-20°C

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H319-H413
Precautionary Statements	P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi
RIDADR	NONH for all modes of transport

{[3-(4-Methoxyphenyl)-4-oxo-3,4,5,6,7,8-hexahydro[1]benzothieno[2,3-d]pyrimidin-2-yl]sulfanyl}acetonitrile

Acetonitrile, 2-[[3,4,5,6,7,8-hexahydro-3-(4-methoxyphenyl)-4-oxo[1]benzothieno[2,3-d]pyrimidin-2-yl]thio]-

Necrostatin-5

Nec-5

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Necrostatin-5
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Purity: 98.0%
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Necrostatin-5

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.