351062-08-3
351062-08-3 structure
- Name: Necrostatin-7
- Chemical Name: (5Z)-5-[[5-(4-fluorophenyl)-1H-pyrazol-4-yl]methylidene]-2-imino-3-(1,3-thiazol-2-yl)-1,3-thiazolidin-4-one
- CAS Number: 351062-08-3
- Molecular Formula: C16H10FN5OS2
- Molecular Weight: 371.412
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2017-03-26 23:11:35
- Modify Date: 2025-08-25 13:01:07
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Necrotatin-7 (Nec-7) is a potent necroptosis inhibitor with an EC50 of 10.6 μM. Necrotatin-7 does not inhibit recombinant RIP1 kinase[1].
| Name | (5Z)-5-[[5-(4-fluorophenyl)-1H-pyrazol-4-yl]methylidene]-2-imino-3-(1,3-thiazol-2-yl)-1,3-thiazolidin-4-one |
|---|---|
| Synonyms |
(5Z)-5-{[3-(4-Fluorophenyl)-1H-pyrazol-4-yl]methylene}-2-imino-3-(1,3-thiazol-2-yl)-1,3-thiazolidin-4-one
HMS621M06 necrotatin-7 Necrostatin-7 Nec-7 5-[[3-(4-Fluorophenyl)-1H-pyrazol-4-yl]methylene]-2-imino-3-(2-thiazolyl)-4-thiazolidinone Nec-7 4-Thiazolidinone, 5-[[3-(4-fluorophenyl)-1H-pyrazol-4-yl]methylene]-2-imino-3-(2-thiazolyl)-, (5Z)- |
| Description | Necrotatin-7 (Nec-7) is a potent necroptosis inhibitor with an EC50 of 10.6 μM. Necrotatin-7 does not inhibit recombinant RIP1 kinase[1]. |
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| Related Catalog | |
| References |
| Density | 1.6±0.1 g/cm3 |
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| Boiling Point | 613.4±65.0 °C at 760 mmHg |
| Molecular Formula | C16H10FN5OS2 |
| Molecular Weight | 371.412 |
| Flash Point | 324.8±34.3 °C |
| Exact Mass | 371.031067 |
| PSA | 139.27000 |
| LogP | 2.73 |
| Vapour Pressure | 0.0±1.8 mmHg at 25°C |
| Index of Refraction | 1.805 |
|
~90%
351062-08-3 |
| Literature: PRESIDENT AND FELLOWS OF HARVARD COLLEGE; SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY, CHINESE ACADEMY OF SCIENCES; YUAN, Junying; YUAN, Chengye; DEGTEREV, Alexei Patent: WO2010/75290 A1, 2010 ; Location in patent: Page/Page column 45 ; |
| Precursor 1 | |
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| DownStream 0 | |