2-Amino-5-phenylpyridine

Modify Date: 2025-08-25 08:18:49

2-Amino-5-phenylpyridine structure	Common Name	2-Amino-5-phenylpyridine
	CAS Number	33421-40-8	Molecular Weight	170.21000
	Density	1.133g/cm3	Boiling Point	323.6ºC at 760mmHg
	Molecular Formula	C₁₁H₁₀N₂	Melting Point	132 °C
	MSDS	USA	Flash Point	175.6ºC

Use of 2-Amino-5-phenylpyridine

2-Amino-5-phenylpyridine is a mutagenic heterocyclic aromatic amine that is formed by pyrolysis of phenylalanine in proteins. 2-Amino-5-phenylpyridine is in broiled sardines and is considered as potentially carcinogenic[1][2].

Name	5-phenylpyridin-2-amine
Synonym	More Synonyms

Description	2-Amino-5-phenylpyridine is a mutagenic heterocyclic aromatic amine that is formed by pyrolysis of phenylalanine in proteins. 2-Amino-5-phenylpyridine is in broiled sardines and is considered as potentially carcinogenic[1][2].
Related Catalog	Research Areas >> Cancer
In Vitro	On the other hand, the chemical structure of 5-phenyl-2-pyridinamine (PPA) shows a great resemblance to the aminobiphenyls, another well known class of carcinogenic aromatic amines[2].
References	[1]. Dooley KL, et al. Comparative carcinogenicity of the food pyrolysis product, 2-amino-5-phenylpyridine, and the known human carcinogen, 4-aminobiphenyl, in the neonatal B6C3F1 mouse. Cancer Lett. 1988 Jul;41(1):99-103. [2]. Stavenuiter JF, et al. Syntheses of 5-phenyl-2-pyridinamine, a possibly carcinogenic pyrolysis product of phenylalanine, and some of its putative metabolites. Carcinogenesis. 1985 Jan;6(1):13-9.

Density	1.133g/cm3
Boiling Point	323.6ºC at 760mmHg
Melting Point	132 °C
Molecular Formula	C₁₁H₁₀N₂
Molecular Weight	170.21000
Flash Point	175.6ºC
Exact Mass	170.08400
PSA	38.91000
LogP	2.91200
Index of Refraction	1.625

2-Amino-5-phenylpyridine MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: US2145000

CHEMICAL NAME :: Pyridine, 2-amino-5-phenyl-

CAS REGISTRY NUMBER :: 33421-40-8

BEILSTEIN REFERENCE NO. :: 0120219

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C11-H10-N2

MOLECULAR WEIGHT :: 170.23

WISWESSER LINE NOTATION :: T6NJ BZ FR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 100 ug/plate

REFERENCE :: CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 26,611,1978

Hazard Codes	Xn
Risk Phrases	36/37/38
Safety Phrases	S26-S36/37/39
RTECS	US2145000

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