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2-Amino-5-phenylpyridine

Names

[ CAS No. ]:
33421-40-8

[ Name ]:
2-Amino-5-phenylpyridine

[Synonym ]:
5-phenyl-2-aminopyridine
5-phenyl-pyridin-2-ylamine
5-phenyl-2-pyridinamine
2-Amino-5-phenylpyridine
2-Pyridinamine,5-phenyl
5-Phenylpyridin-2-amine
MFCD01692452
Pyridine,2-amino-5-phenyl
Phe-P-1

Biological Activity

[Description]:

2-Amino-5-phenylpyridine is a mutagenic heterocyclic aromatic amine that is formed by pyrolysis of phenylalanine in proteins. 2-Amino-5-phenylpyridine is in broiled sardines and is considered as potentially carcinogenic[1][2].

[Related Catalog]:

Research Areas >> Cancer

[In Vitro]

On the other hand, the chemical structure of 5-phenyl-2-pyridinamine (PPA) shows a great resemblance to the aminobiphenyls, another well known class of carcinogenic aromatic amines[2].

[References]

[1]. Dooley KL, et al. Comparative carcinogenicity of the food pyrolysis product, 2-amino-5-phenylpyridine, and the known human carcinogen, 4-aminobiphenyl, in the neonatal B6C3F1 mouse. Cancer Lett. 1988 Jul;41(1):99-103.

[2]. Stavenuiter JF, et al. Syntheses of 5-phenyl-2-pyridinamine, a possibly carcinogenic pyrolysis product of phenylalanine, and some of its putative metabolites. Carcinogenesis. 1985 Jan;6(1):13-9.

Chemical & Physical Properties

[ Density]:
1.133g/cm3

[ Boiling Point ]:
323.6ºC at 760mmHg

[ Melting Point ]:
132 °C

[ Molecular Formula ]:
C11H10N2

[ Molecular Weight ]:
170.21000

[ Flash Point ]:
175.6ºC

[ Exact Mass ]:
170.08400

[ PSA ]:
38.91000

[ LogP ]:
2.91200

[ Index of Refraction ]:
1.625

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
US2145000
CHEMICAL NAME :
Pyridine, 2-amino-5-phenyl-
CAS REGISTRY NUMBER :
33421-40-8
BEILSTEIN REFERENCE NO. :
0120219
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C11-H10-N2
MOLECULAR WEIGHT :
170.23
WISWESSER LINE NOTATION :
T6NJ BZ FR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :
Mutation in microorganisms
TEST SYSTEM :
Bacteria - Salmonella typhimurium
DOSE/DURATION :
100 ug/plate
REFERENCE :
CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 26,611,1978

Safety Information

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
S26-S36/37/39

[ RTECS ]:
US2145000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds