oleic acid

Modify Date: 2025-08-21 07:07:25

oleic acid structure	Common Name	oleic acid
	CAS Number	112-80-1	Molecular Weight	282.461
	Density	0.9±0.1 g/cm3	Boiling Point	360.0±0.0 °C at 760 mmHg
	Molecular Formula	C₁₈H₃₄O₂	Melting Point	13-14 °C(lit.)
	MSDS	Chinese USA	Flash Point	270.1±14.4 °C
	Symbol	GHS07	Signal Word	Warning

Use of oleic acid

Oleic acid is an abundant monounsaturated fatty acid.

Name	oleic acid
Synonym	More Synonyms

Description	Oleic acid is an abundant monounsaturated fatty acid.
Related Catalog	Natural Products >> Acids and Aldehydes Research Areas >> Others
Target	Human Endogenous Metabolite
In Vitro	Oleic acid is the most common monounsaturated fatty acids (FA) in human adipocytes and other tissues. Oleic acid prompts cell proliferation and migration in high metastatic cancer cells via enhancing β-oxidation mediated by AMPK activation. Oleic acid inhibits cancer cell growth and survival in low metastatic carcinoma cells, such as gastric carcinoma SGC7901 and breast carcinoma MCF-7 cell lines[1].
References	[1]. Li S, et al. High metastaticgastric and breast cancer cells consume oleic acid in an AMPK dependent manner. PLoS One. 2014 May 13;9(5):e97330.

Density	0.9±0.1 g/cm3
Boiling Point	360.0±0.0 °C at 760 mmHg
Melting Point	13-14 °C(lit.)
Molecular Formula	C₁₈H₃₄O₂
Molecular Weight	282.461
Flash Point	270.1±14.4 °C
Exact Mass	282.255890
PSA	37.30000
LogP	7.70
Vapour density	1.03 (vs air)
Vapour Pressure	0.0±1.7 mmHg at 25°C
Index of Refraction	1.467
Storage condition	2-8°C
Stability	Stable. Combustible. Incompatible with strong oxidizing agents, aluminium.
Water Solubility	negligible

oleic acid MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RG2275000

CHEMICAL NAME :: 9-Octadecenoic acid, (Z)-

CAS REGISTRY NUMBER :: 112-80-1

BEILSTEIN REFERENCE NO. :: 1726542

LAST UPDATED :: 199710

DATA ITEMS CITED :: 17

MOLECULAR FORMULA :: C18-H34-O2

MOLECULAR WEIGHT :: 282.52

WISWESSER LINE NOTATION :: QV8U9 -C

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Human

TYPE OF TEST :: Open irritation test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 74 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2400 ug/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - acute pulmonary edema Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 282 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 230 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 390 mg/kg/17W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application

TYPE OF TEST :: Unscheduled DNA synthesis

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Rodent - hamster Fibroblast

DOSE/DURATION :: 2500 ug/L

REFERENCE :: CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 3,499,1982 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 52190 No. of Facilities: 65952 (estimated) No. of Industries: 312 No. of Occupations: 196 No. of Employees: 796897 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 52190 No. of Facilities: 49332 (estimated) No. of Industries: 256 No. of Occupations: 181 No. of Employees: 1078478 (estimated) No. of Female Employees: 410362 (estimated)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315
Personal Protective Equipment	Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	Xi:Irritant
Risk Phrases	R36/37/38
Safety Phrases	S36/37-S37/39-S26-S36
RIDADR	UN 1198 3/PG 3
WGK Germany	2
RTECS	LP8925000
HS Code	2916150000

Precursor 8
CAS#:112-77-6 OLEIC ACID CHLORIDE CAS#:112-62-9 Methyl oleate CAS#:122-32-7 Glycerine trioleate CAS#:111-62-6 Ethyl Oleate
CAS#:6085-36-5 [(E)-octadec-9-... CAS#:114119-34-5 methyl 5-thiast... CAS#:506-24-1 Stearolic acid CAS#:112-91-4 oleonitrile
DownStream 10
CAS#:109-28-4 9-Octadecenamid... CAS#:107743-37-3 N-Oleoyl-L-Serine CAS#:104855-14-3 10-iodooctadeca... CAS#:109-39-7 2-butoxyethyl oleate
CAS#:106-12-7 2-(2-hydroxyeth... CAS#:111-10-4 Methoxyethyl oleate CAS#:1120-44-1 COPPER(II) OLEATE CAS#:10468-30-1 cadmium dioleate
CAS#:103634-10-2 [R-(Z)]-4-Hydro... CAS#:109-36-4 octyl stearate

HS Code	2916150000
Summary	2916150000 oleic, linoleic or linolenic acids, their salts and esters。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

Differential expression of efflux pump genes of Mycobacterium tuberculosis in response to varied subinhibitory concentrations of antituberculosis agents.

Tuberculosis (Edinb.) 95(2) , 155-61, (2015)

Several reports have elaborated on the role of efflux pumps in drug resistance in Mycobacterium tuberculosis by analysing the mRNA expression profiles. However, there is no uniformity in the subinhibi...

Decreased lipogenesis in white adipose tissue contributes to the resistance to high fat diet-induced obesity in phosphatidylethanolamine N-methyltransferase-deficient mice.

Biochim. Biophys. Acta 1851(2) , 152-62, (2015)

Mice lacking phosphatidylethanolamine N-methyltransferase (PEMT, Pemt(-/-) mice) are resistant to high-fat diet (HFD)-induced obesity (DIO) but develop non-alcoholic steatohepatitis. PEMT expression i...

Exploring the impact of drug properties on the extent of intestinal lymphatic transport - in vitro and in vivo studies.

Pharm. Res. 32(5) , 1817-29, (2015)

Intestinal lymphatic transport of specific lipophilic drugs offers therapeutic advantages and maximises oral bioavailability. The aims of this study were; to compare intestinal lymphatic transport of ...

oleicacidamide-heptaglycolether

Oleic Acid

adogen73

Amide O

OLEAMID

Armid O

Slip-eze

AMD-O

octadec-9-enoic acid

MFCD00003274

EINECS 200-001-8

cis-9-octadecenamide

cis-oleamide

cis-9-Octadecenoic acid

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: oleic acid
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China
Product Name: oleic acid
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DC Chemicals Limited
China
Product Name: cis-9-Octadecenoic acid
Price: $280.0/20mg
Purity: 98.0%
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Oleic acid
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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Price: ￥2952/10 mM * 1 mL in DMSO

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oleic acid

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