(Gly14)-Humanin (human) trifluoroacetate salt
Modify Date: 2024-02-04 18:11:28
(Gly14)-Humanin (human) trifluoroacetate salt structure
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Common Name | (Gly14)-Humanin (human) trifluoroacetate salt | ||
|---|---|---|---|---|
| CAS Number | 330936-70-4 | Molecular Weight | 2657.21000 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C118H202N34O31S2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of (Gly14)-Humanin (human) trifluoroacetate salt(Gly14)-Humanin (human) (14-Glycine-Humanin (human)) is an analog of Humanin in which the 14th amino acid serine was replaced with glycine (Gly). (Gly14)-Humanin (human) has anti-apoptotic and neuroprotective functions[1][2]. |
| Name | (gly14)-humanin (human) |
|---|---|
| Synonym | More Synonyms |
| Description | (Gly14)-Humanin (human) (14-Glycine-Humanin (human)) is an analog of Humanin in which the 14th amino acid serine was replaced with glycine (Gly). (Gly14)-Humanin (human) has anti-apoptotic and neuroprotective functions[1][2]. |
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| Related Catalog | |
| In Vitro | (Gly14)-Humanin (human) (0.1-10 μM; 72 hours) 显着增加细胞活力，降低 HUVEC 的核荧光、裂解 PARP 水平、ROS 形成和 bax/bcl-2 比值 。并降低 bax 的mRNA水平，增加 bcl-2 的 mRNA 水平[1]。 Cell Viability Assay[1] Cell Line: Human umbilical vein endothelial cells (HUVECs) Concentration: 100 nM, 1 μM and 10 μM Incubation Time: Pretreatment 3 hours and then treated with 72 hours Result: Significantly increased cell viability. Western Blot Analysis[1] Cell Line: Human umbilical vein endothelial cells (HUVECs) Concentration: 1 μM Incubation Time: Pretreatment 3 hours and then treated with 72 hours Result: Reduced the ratio of bax/bcl-2. |
| In Vivo | (Gly14)-Humanin (human)（0.1 μg/5 μL；i.c.v.；一次）减少受损皮层和海马体中具有质膜通透性的细胞，减少脑损伤体积，改善运动性能并改善莫里斯水迷宫试验中的性能[2]。 Animal Model: Adult male CD-1 mice (25-30 g; 10-12-week-old) bearing traumatic brain injury (TBI)[2] Dosage: 0.1 μg/5 μL Administration: Intracerebroventricularly (i.c.v.); once Result: Decreased cells with plasmalemma permeability in the injured cortex and hippocampus, reduced brain lesion volume, improved motor performance. |
| References |
| Molecular Formula | C118H202N34O31S2 |
|---|---|
| Molecular Weight | 2657.21000 |
| Exact Mass | 2655.47000 |
| PSA | 1105.92000 |
| LogP | 5.41140 |
| WGK Germany | 3 |
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- Zhejiang Hangyu API Co., Ltd
- China
- Product Name: (Gly14)-Humanin (human)
- Price: $Inquiry/1kg
- Purity: 99.0%
- Stocking Period: 1 Day
- Contact: Vinnie
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