(Gly14)-Humanin (human) trifluoroacetate salt

Modify Date: 2024-02-04 18:11:28

(Gly14)-Humanin (human) trifluoroacetate salt structure	Common Name	(Gly14)-Humanin (human) trifluoroacetate salt
	CAS Number	330936-70-4	Molecular Weight	2657.21000
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₁₈H₂₀₂N₃₄O₃₁S₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of (Gly14)-Humanin (human) trifluoroacetate salt

(Gly14)-Humanin (human) (14-Glycine-Humanin (human)) is an analog of Humanin in which the 14th amino acid serine was replaced with glycine (Gly). (Gly14)-Humanin (human) has anti-apoptotic and neuroprotective functions[1][2].

Name	(gly14)-humanin (human)
Synonym	More Synonyms

Description	(Gly14)-Humanin (human) (14-Glycine-Humanin (human)) is an analog of Humanin in which the 14th amino acid serine was replaced with glycine (Gly). (Gly14)-Humanin (human) has anti-apoptotic and neuroprotective functions[1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Neurological Disease
In Vitro	(Gly14)-Humanin (human) (0.1-10 μM; 72 hours) 显着增加细胞活力，降低 HUVEC 的核荧光、裂解 PARP 水平、ROS 形成和 bax/bcl-2 比值。并降低 bax 的mRNA水平，增加 bcl-2 的 mRNA 水平[1]。 Cell Viability Assay[1] Cell Line: Human umbilical vein endothelial cells (HUVECs) Concentration: 100 nM, 1 μM and 10 μM Incubation Time: Pretreatment 3 hours and then treated with 72 hours Result: Significantly increased cell viability. Western Blot Analysis[1] Cell Line: Human umbilical vein endothelial cells (HUVECs) Concentration: 1 μM Incubation Time: Pretreatment 3 hours and then treated with 72 hours Result: Reduced the ratio of bax/bcl-2.
In Vivo	(Gly14)-Humanin (human)（0.1 μg/5 μL；i.c.v.；一次）减少受损皮层和海马体中具有质膜通透性的细胞，减少脑损伤体积，改善运动性能并改善莫里斯水迷宫试验中的性能[2]。 Animal Model: Adult male CD-1 mice (25-30 g; 10-12-week-old) bearing traumatic brain injury (TBI)[2] Dosage: 0.1 μg/5 μL Administration: Intracerebroventricularly (i.c.v.); once Result: Decreased cells with plasmalemma permeability in the injured cortex and hippocampus, reduced brain lesion volume, improved motor performance.
References	[1]. Ying Xie, et al. Protection effect of [Gly14]-Humanin from apoptosis induced by high glucose in human umbilical vein endothelial cells. Diabetes Res Clin Pract. 2014 Dec;106(3):560-6. [2]. T Wang, et al. [Gly14]-Humanin reduces histopathology and improves functional outcome after traumatic brain injury in mice. Neuroscience. 2013 Feb 12;231:70-81.

Molecular Formula	C₁₁₈H₂₀₂N₃₄O₃₁S₂
Molecular Weight	2657.21000
Exact Mass	2655.47000
PSA	1105.92000
LogP	5.41140

WGK Germany	3

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(Gly14)-Humanin (human) trifluoroacetate salt

Use of (Gly14)-Humanin (human) trifluoroacetate salt

Names

Biological Activity

Chemical & Physical Properties

Safety Information

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.