Humanin (human) trifluoroacetate salt

Modify Date: 2024-01-02 17:22:15

Humanin (human) trifluoroacetate salt Structure
Humanin (human) trifluoroacetate salt structure
Common Name Humanin (human) trifluoroacetate salt
CAS Number 330936-69-1 Molecular Weight 2687.23000
Density 1.43±0.1 g/cm3(Predicted) Boiling Point N/A
Molecular Formula C119H204N34O32S2 Melting Point N/A
MSDS USA Flash Point N/A

 Use of Humanin (human) trifluoroacetate salt


Humanin, an anti-apoptotic peptide of 24 amino acids, is a Bax inhibitor. Humanin prevents the translocation of Bax from cytosol to mitochondria, blocks Bax from the inactive to active conformation. Humanin is a mitochondria-associated peptide with a neuroprotective effect against AD-related neurotoxicity. Humanin also improves overall insulin sensitivity in animal. Humanin are related to aging[1][2]. Humanin analogue, in which the serine at position 14 is replaced by glycine, names HNG[2].

 Names

Name Humanin
Synonym More Synonyms

 Humanin (human) trifluoroacetate salt Biological Activity

Description Humanin, an anti-apoptotic peptide of 24 amino acids, is a Bax inhibitor. Humanin prevents the translocation of Bax from cytosol to mitochondria, blocks Bax from the inactive to active conformation. Humanin is a mitochondria-associated peptide with a neuroprotective effect against AD-related neurotoxicity. Humanin also improves overall insulin sensitivity in animal. Humanin are related to aging[1][2]. Humanin analogue, in which the serine at position 14 is replaced by glycine, names HNG[2].
Related Catalog
Target

Bax

In Vitro Humanin (40 nM,罗丹明偶联;30 min) 抑制野生型 HCT116 细胞受 Bax 蛋白诱导的细胞死亡[1]。 Humanin (100 μM;10 min) 阻断 Bax 与分离线粒体的关联,并抑制野生型 HCT116 细胞中细胞色素 c 的释放[1]。 Humanin 减少 0.2 mM STS 诱导的细胞半凋亡[1]。 Humanin 不能抑制 Bax 缺陷的 HCT116 细胞的凋亡[1]。
In Vivo Humanin (0.375 mg/kg/hr; 静脉注射) 增加 Zucker 糖尿病脂肪 (ZDF) 大鼠对外周胰岛素敏感性[2]。
References

[1]. Guo B, et al. Humanin peptide suppresses apoptosis by interfering with Bax activation. Nature. 2003 May 22;423(6938):456-61.  

[2]. Muzumdar RH, et al. Humanin: a novel central regulator of peripheral insulin action. PLoS One. 2009 Jul 22;4(7):e6334.  

 Chemical & Physical Properties

Density 1.43±0.1 g/cm3(Predicted)
Molecular Formula C119H204N34O32S2
Molecular Weight 2687.23000
Exact Mass 2685.48000
PSA 1126.15000
LogP 4.77230
Storage condition -20°C

 Safety Information

Hazard Codes Xn

 Synonyms

1-24-Protein humanin (human)
Protein (human clone 1 humanin sequence homolog)
MET-ALA-PRO-ARG-GLY-PHE-SER-CYS-LEU-LEU-LEU-LEU-THR-SER-GLU-ILE-ASP-LEU-PRO-VAL-LYS-ARG-ARG-ALA
MAPRGFSCLLLLTSEIDLPVKRRA
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