Humanin (human) trifluoroacetate salt

Modify Date: 2024-01-02 17:22:15

Humanin (human) trifluoroacetate salt structure	Common Name	Humanin (human) trifluoroacetate salt
	CAS Number	330936-69-1	Molecular Weight	2687.23000
	Density	1.43±0.1 g/cm3(Predicted)	Boiling Point	N/A
	Molecular Formula	C₁₁₉H₂₀₄N₃₄O₃₂S₂	Melting Point	N/A
	MSDS	USA	Flash Point	N/A

Use of Humanin (human) trifluoroacetate salt

Humanin, an anti-apoptotic peptide of 24 amino acids, is a Bax inhibitor. Humanin prevents the translocation of Bax from cytosol to mitochondria, blocks Bax from the inactive to active conformation. Humanin is a mitochondria-associated peptide with a neuroprotective effect against AD-related neurotoxicity. Humanin also improves overall insulin sensitivity in animal. Humanin are related to aging[1][2]. Humanin analogue, in which the serine at position 14 is replaced by glycine, names HNG[2].

Name	Humanin
Synonym	More Synonyms

Description	Humanin, an anti-apoptotic peptide of 24 amino acids, is a Bax inhibitor. Humanin prevents the translocation of Bax from cytosol to mitochondria, blocks Bax from the inactive to active conformation. Humanin is a mitochondria-associated peptide with a neuroprotective effect against AD-related neurotoxicity. Humanin also improves overall insulin sensitivity in animal. Humanin are related to aging[1][2]. Humanin analogue, in which the serine at position 14 is replaced by glycine, names HNG[2].
Related Catalog	Signaling Pathways >> Apoptosis >> Bcl-2 Family Research Areas >> Endocrinology Research Areas >> Neurological Disease
Target	Bax
In Vitro	Humanin (40 nM，罗丹明偶联；30 min) 抑制野生型 HCT116 细胞受 Bax 蛋白诱导的细胞死亡[1]。 Humanin (100 μM；10 min) 阻断 Bax 与分离线粒体的关联，并抑制野生型 HCT116 细胞中细胞色素 c 的释放[1]。 Humanin 减少 0.2 mM STS 诱导的细胞半凋亡[1]。 Humanin 不能抑制 Bax 缺陷的 HCT116 细胞的凋亡[1]。
In Vivo	Humanin (0.375 mg/kg/hr; 静脉注射) 增加 Zucker 糖尿病脂肪 (ZDF) 大鼠对外周胰岛素敏感性[2]。
References	[1]. Guo B, et al. Humanin peptide suppresses apoptosis by interfering with Bax activation. Nature. 2003 May 22;423(6938):456-61. [2]. Muzumdar RH, et al. Humanin: a novel central regulator of peripheral insulin action. PLoS One. 2009 Jul 22;4(7):e6334.

Density	1.43±0.1 g/cm3(Predicted)
Molecular Formula	C₁₁₉H₂₀₄N₃₄O₃₂S₂
Molecular Weight	2687.23000
Exact Mass	2685.48000
PSA	1126.15000
LogP	4.77230
Storage condition	-20°C