KH 7

Modify Date: 2025-08-25 14:42:26

KH 7 Structure
KH 7 structure
Common Name KH 7
CAS Number 330676-02-3 Molecular Weight 419.296
Density 1.6±0.1 g/cm3 Boiling Point N/A
Molecular Formula C17H15BrN4O2S Melting Point N/A
MSDS USA Flash Point N/A
Symbol GHS06
GHS06
Signal Word Danger

 Use of KH 7


KH7 is a soluble adenylyl cyclase (sAC)-specific inhibitor, with IC50s of 3-10 μM toward both recombinant purified human sACt protein and heterologously expressed sACt in cellular assays[1].

 Names

Name 2-(1H-benzimidazol-2-ylsulfanyl)-N'-[(3-bromo-6-oxocyclohexa-2,4-dien-1-ylidene)methyl]propanehydrazide
Synonym More Synonyms

 KH 7 Biological Activity

Description KH7 is a soluble adenylyl cyclase (sAC)-specific inhibitor, with IC50s of 3-10 μM toward both recombinant purified human sACt protein and heterologously expressed sACt in cellular assays[1].
Related Catalog
Target

IC50: 3-10 μM (recombinant sACt)[1].

References

[1]. Hess KC, et al. The "soluble" adenylyl cyclase in sperm mediates multiple signaling events required for fertilization. Dev Cell. 2005 Aug;9(2):249-59.

 Chemical & Physical Properties

Density 1.6±0.1 g/cm3
Molecular Formula C17H15BrN4O2S
Molecular Weight 419.296
Exact Mass 418.009888
PSA 115.67000
LogP 6.01
Index of Refraction 1.716
Storage condition 2-8℃

 Safety Information

Symbol GHS06
GHS06
Signal Word Danger
Hazard Statements H301
Precautionary Statements P301 + P310
RIDADR UN 2811 6.1 / PGIII

 Articles5

More Articles
Prostaglandin E2 Inhibits NLRP3 Inflammasome Activation through EP4 Receptor and Intracellular Cyclic AMP in Human Macrophages.

J. Immunol. 194 , 5472-87, (2015)

PGE2 is a potent lipid mediator involved in maintaining homeostasis but also promotion of acute inflammation or immune suppression in chronic inflammation and cancer. Nucleotide-binding domain, leucin...

Endothelial CD99 signals through soluble adenylyl cyclase and PKA to regulate leukocyte transendothelial migration.

J. Exp. Med. 212 , 1021-41, (2015)

CD99 is a critical regulator of leukocyte transendothelial migration (TEM). How CD99 signals during this process remains unknown. We show that during TEM, endothelial cell (EC) CD99 activates protein ...

Short- and long-term regulation of intestinal Na+/H+ exchange by Toll-like receptors TLR4 and TLR5.

Am. J. Physiol. Gastrointest. Liver Physiol. 309 , G703-15, (2015)

Inappropriate activation of pattern recognition receptors has been described as a potential trigger in the development of inflammatory bowel disease (IBD). In this study, we evaluated the activity and...

 Synonyms

Propanoic acid, 2-(1H-benzimidazol-2-ylthio)-, 2-[(1E)-(5-bromo-2-hydroxyphenyl)methylene]hydrazide
2-(1H-Benzimidazol-2-ylsulfanyl)-N'-[(E)-(5-bromo-2-hydroxyphenyl)methylene]propanehydrazide
MNI-caged-L-glutamate
KH7
(E)-2-(1H-Benzo[d]imidazol-2-ylthio)-N'-(5-bromo-2-hydroxybenzylidene)propanehydrazide
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