KH-176
Modify Date: 2025-08-25 18:08:10
KH-176 structure
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Common Name | KH-176 | ||
|---|---|---|---|---|
| CAS Number | 1541170-75-5 | Molecular Weight | 332.437 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 570.8±50.0 °C at 760 mmHg | |
| Molecular Formula | C19H28N2O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 299.0±30.1 °C | |
Use of KH-176KH-176 (KH176, Sonlicromanol) is a smal molecule ROS-redox modulator, effectively reduces increased cellular ROS levels and protects OXPHOS deficient primary cells against redox perturbation by targeting the Thioredoxin/Peroxiredoxin system; significantly improves rotarod and gait performance and reduces the degeneration of retinal ganglion cells in Ndufs4 -/- mice, shows therapeutic effects in mammalian model of Leigh Disease. |
| Name | KH-176 |
|---|---|
| Synonym | More Synonyms |
| Description | KH-176 (KH176, Sonlicromanol) is a smal molecule ROS-redox modulator, effectively reduces increased cellular ROS levels and protects OXPHOS deficient primary cells against redox perturbation by targeting the Thioredoxin/Peroxiredoxin system; significantly improves rotarod and gait performance and reduces the degeneration of retinal ganglion cells in Ndufs4 -/- mice, shows therapeutic effects in mammalian model of Leigh Disease. |
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| References | References 1. de Haas R, et al. Sci Rep. 2017 Sep 15;7(1):11733. 2. Koene S, et al. Orphanet J Rare Dis. 2017 Oct 16;12(1):163. 3. Beyrath J, et al. Sci Rep. 2018 Apr 26;8(1):6577. View Related Products by Target Adenosine Receptor |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 570.8±50.0 °C at 760 mmHg |
| Molecular Formula | C19H28N2O3 |
| Molecular Weight | 332.437 |
| Flash Point | 299.0±30.1 °C |
| Exact Mass | 332.209991 |
| LogP | 2.39 |
| Vapour Pressure | 0.0±1.6 mmHg at 25°C |
| Index of Refraction | 1.583 |
| InChIKey | LZYWLEPSQNXESC-KUHUBIRLSA-N |
| SMILES | Cc1c(C)c2c(c(C)c1O)CCC(C)(C(=O)NC1CCCNC1)O2 |
| 2H-1-Benzopyran-2-carboxamide, 3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-N-[(3R)-3-piperidinyl]-, (2S)- |
| KH-176 |
| JCU3O35RDS |
| (2S)-6-Hydroxy-2,5,7,8-tetramethyl-N-[(3R)-3-piperidinyl]-2-chromanecarboxamide |