AMG-176

Modify Date: 2024-01-07 22:05:07

AMG-176 structure	Common Name	AMG-176
	CAS Number	1883727-34-1	Molecular Weight	613.21
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₃H₄₁ClN₂O₅S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of AMG-176

AMG-176 is a potent, selective and orally bioavailable MCL-1 inhibitor, with a Ki of 0.13 nM.

Name	AMG176

Description	AMG-176 is a potent, selective and orally bioavailable MCL-1 inhibitor, with a Ki of 0.13 nM.
Related Catalog	Signaling Pathways >> Apoptosis >> Bcl-2 Family Research Areas >> Cancer
Target	Mcl-1:0.13 nM (Ki)
In Vitro	AMG-176 is an inhibitor of induced myeloid leukemia cell differentiation protein MCL-1 (Ki=0.13 nM), with potential pro-apoptotic and antineoplastic activities. Upon administration, AMG 176 binds to and inhibits the activity of MCL-1. This disrupts the formation of MCL-1/Bcl-2-like protein 11 (BCL2L11; BIM) complexes and induces apoptosis in tumor cells[1][2].
References	[1]. Caenepeel S, et al. AMG 176, a Selective MCL1 Inhibitor, is Effective in Hematological Cancer Models Alone and in Combination with Established Therapies. Cancer Discov. 2018 Sep 25. pii: CD-18-0387. [2]. Garner TP, et al. Progress in targeting the BCL-2 family of proteins. Curr Opin Chem Biol. 2017 Aug;39:133-142.

Molecular Formula	C₃₃H₄₁ClN₂O₅S
Molecular Weight	613.21
Storage condition	2-8℃

DC Chemicals Limited
China
Product Name: AMG-176
Price: $1900.0/250mg $3800.0/1g $950.0/100mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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Price: ￥17538/10 mM * 1 mL in DMSO

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