1883727-34-1

1883727-34-1 structure

Name: AMG-176
Chemical Name: AMG176
CAS Number: 1883727-34-1
Molecular Formula: C₃₃H₄₁ClN₂O₅S
Molecular Weight: 613.21
Catalog: Signaling Pathways Apoptosis Bcl-2 Family
Create Date: 2018-02-01 14:09:57
Modify Date: 2024-01-07 22:05:07
AMG-176 is a potent, selective and orally bioavailable MCL-1 inhibitor, with a Ki of 0.13 nM.

Name	AMG176

Description	AMG-176 is a potent, selective and orally bioavailable MCL-1 inhibitor, with a Ki of 0.13 nM.
Related Catalog	Signaling Pathways >> Apoptosis >> Bcl-2 Family Research Areas >> Cancer
Target	Mcl-1:0.13 nM (Ki)
In Vitro	AMG-176 is an inhibitor of induced myeloid leukemia cell differentiation protein MCL-1 (Ki=0.13 nM), with potential pro-apoptotic and antineoplastic activities. Upon administration, AMG 176 binds to and inhibits the activity of MCL-1. This disrupts the formation of MCL-1/Bcl-2-like protein 11 (BCL2L11; BIM) complexes and induces apoptosis in tumor cells[1][2].
References	[1]. Caenepeel S, et al. AMG 176, a Selective MCL1 Inhibitor, is Effective in Hematological Cancer Models Alone and in Combination with Established Therapies. Cancer Discov. 2018 Sep 25. pii: CD-18-0387. [2]. Garner TP, et al. Progress in targeting the BCL-2 family of proteins. Curr Opin Chem Biol. 2017 Aug;39:133-142.