KH 7

Names

[ Name ]:
KH 7

[Synonym ]:
Propanoic acid, 2-(1H-benzimidazol-2-ylthio)-, 2-[(1E)-(5-bromo-2-hydroxyphenyl)methylene]hydrazide
2-(1H-Benzimidazol-2-ylsulfanyl)-N'-[(E)-(5-bromo-2-hydroxyphenyl)methylene]propanehydrazide
MNI-caged-L-glutamate
KH7
(E)-2-(1H-Benzo[d]imidazol-2-ylthio)-N'-(5-bromo-2-hydroxybenzylidene)propanehydrazide

Biological Activity

[Description]:

KH7 is a soluble adenylyl cyclase (sAC)-specific inhibitor, with IC50s of 3-10 μM toward both recombinant purified human sACt protein and heterologously expressed sACt in cellular assays[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[Target]

IC50: 3-10 μM (recombinant sACt)[1].

[References]

[1]. Hess KC, et al. The "soluble" adenylyl cyclase in sperm mediates multiple signaling events required for fertilization. Dev Cell. 2005 Aug;9(2):249-59.

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Molecular Formula ]:
C₁₇H₁₅BrN₄O₂S

[ Molecular Weight ]:
419.296

[ Exact Mass ]:
418.009888

[ PSA ]:
115.67000

[ LogP ]:
6.01

[ Index of Refraction ]:
1.716

[ Storage condition ]:
2-8℃

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301

[ Precautionary Statements ]:
P301 + P310

[ RIDADR ]:
UN 2811 6.1 / PGIII

Articles

Prostaglandin E2 Inhibits NLRP3 Inflammasome Activation through EP4 Receptor and Intracellular Cyclic AMP in Human Macrophages.

J. Immunol. 194 , 5472-87, (2015)

PGE2 is a potent lipid mediator involved in maintaining homeostasis but also promotion of acute inflammation or immune suppression in chronic inflammation and cancer. Nucleotide-binding domain, leucin...

Endothelial CD99 signals through soluble adenylyl cyclase and PKA to regulate leukocyte transendothelial migration.

J. Exp. Med. 212 , 1021-41, (2015)

CD99 is a critical regulator of leukocyte transendothelial migration (TEM). How CD99 signals during this process remains unknown. We show that during TEM, endothelial cell (EC) CD99 activates protein ...

Short- and long-term regulation of intestinal Na+/H+ exchange by Toll-like receptors TLR4 and TLR5.

Am. J. Physiol. Gastrointest. Liver Physiol. 309 , G703-15, (2015)

Inappropriate activation of pattern recognition receptors has been described as a potential trigger in the development of inflammatory bowel disease (IBD). In this study, we evaluated the activity and...

Related Compounds

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