Dihydroxythiobinupharidine

Modify Date: 2024-04-05 22:04:02

Dihydroxythiobinupharidine Structure
Dihydroxythiobinupharidine structure
Common Name Dihydroxythiobinupharidine
CAS Number 30343-70-5 Molecular Weight 526.73
Density 1.3±0.1 g/cm3 Boiling Point 667.3±55.0 °C at 760 mmHg
Molecular Formula C30H42N2O4S Melting Point N/A
MSDS N/A Flash Point 357.4±31.5 °C

 Use of Dihydroxythiobinupharidine


6,6′-Dihydroxythiobinupharidine is a cysteine proteases inhibitor. 6,6′-Dihydroxythiobinupharidine can enhance DNA cleavage mediated by human topoisomerase IIα and IIβ ~8-fold and ~3-fold, respectively[1][2].

 Names

Name (+)-6,6'-dihydroxythiobinupharidine
Synonym More Synonyms

 Dihydroxythiobinupharidine Biological Activity

Description 6,6′-Dihydroxythiobinupharidine is a cysteine proteases inhibitor. 6,6′-Dihydroxythiobinupharidine can enhance DNA cleavage mediated by human topoisomerase IIα and IIβ ~8-fold and ~3-fold, respectively[1][2].
Related Catalog
References

[1]. YamaharaJ, et al. Potent immunosuppressive principles, dimeric sesquiterpenethioalkaloids, isolated from nupharis rhizoma, the rhizoma of Nuphar pumilum(nymphaeaceae): structure-requirement of nuphar-alkaloid for immunosuppressiveactivity. Biol Pharm Bull. 1996;19(9):1241-1243.  

[2]. DalvieED, et al. 6,6'-Dihydroxythiobinupharidine as a poison of human type IItopoisomerases. Bioorg Med Chem Lett. 2019;29(15):1881-1885.  

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 667.3±55.0 °C at 760 mmHg
Molecular Formula C30H42N2O4S
Molecular Weight 526.73
Flash Point 357.4±31.5 °C
Exact Mass 526.286499
LogP 4.57
Vapour Pressure 0.0±2.1 mmHg at 25°C
Index of Refraction 1.645

 Synonyms

6,6'-dihydroxythiobinupharidine
Dispiro[2H-quinolizine-3(4H),2'(3'H)-thiophene-4'(5'H),3''(4''H)-[2H]quinolizine]-4,4''-diol, 6,6''-di-3-furanyldodecahydro-9,9''-dimethyl-, (3S,4R,4'S,4''R,6S,6''S,9R,9''R,9aS,9a''S)-
(3S,4R,4'S,4''R,6S,6''S,9R,9''R,9aS,9a''S)-6,6''-Di(3-furyl)-9,9''-dimethyldodecahydro-2H,2''H-dispiro[quinolizine-3,2'-thiophene-4',3''-quinolizine]-4,4''-diol
(3S,4R,4'S,4''R,6S,6''S,9R,9''R,9aS,9a''S)-6,6''-di(furan-3-yl)-9,9''-dimethyldodecahydro-2H,2''H-dispiro[quinolizine-3,2'-thiophene-4',3''-quinolizine]-4,4''-diol
(+)-6,6'-dihydroxythiobinupharidine