Dihydroxythiobinupharidine

• 常用名: Dihydroxythiobinupharidine
• 英文名: Dihydroxythiobinupharidine
• CAS号: 30343-70-5
• 分子量: 526.73
• 密度: 1.3±0.1 g/cm3
• 沸点: 667.3±55.0 °C at 760 mmHg
• 分子式: C₃₀H₄₂N₂O₄S
• 熔点: N/A
• 闪点: 357.4±31.5 °C

Dihydroxythiobinupharidine用途

6,6′-Dihydroxythiobinupharidine 是一种半胱氨酸蛋白酶 (cysteine proteases) 抑制剂。6,6′-Dihydroxythiobinupharidine 对人拓扑异构酶IIα和IIβ (topoisomerase IIα, IIβ) 介导的 DNA 裂解分别有 8 倍和 3 倍的促进作用。

Dihydroxythiobinupharidine名称

• 英文名: (+)-6,6'-dihydroxythiobinupharidine

Dihydroxythiobinupharidine生物活性

• 描述: 6,6′-Dihydroxythiobinupharidine 是一种半胱氨酸蛋白酶 (cysteine proteases) 抑制剂。6,6′-Dihydroxythiobinupharidine 对人拓扑异构酶IIα和IIβ (topoisomerase IIα, IIβ) 介导的 DNA 裂解分别有 8 倍和 3 倍的促进作用。
• 相关类别:
  研究领域 >> 其他
  信号通路 >> 代谢酶/蛋白酶 >> 组织蛋白酶
• 参考文献:

  [1]. YamaharaJ, et al. Potent immunosuppressive principles, dimeric sesquiterpenethioalkaloids, isolated from nupharis rhizoma, the rhizoma of Nuphar pumilum(nymphaeaceae): structure-requirement of nuphar-alkaloid for immunosuppressiveactivity. Biol Pharm Bull. 1996;19(9):1241-1243.

  [2]. DalvieED, et al. 6,6'-Dihydroxythiobinupharidine as a poison of human type IItopoisomerases. Bioorg Med Chem Lett. 2019;29(15):1881-1885.

Dihydroxythiobinupharidine物理化学性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 667.3±55.0 °C at 760 mmHg
• 分子式: C₃₀H₄₂N₂O₄S
• 分子量: 526.73
• 闪点: 357.4±31.5 °C
• 精确质量: 526.286499
• LogP: 4.57
• 蒸汽压: 0.0±2.1 mmHg at 25°C
• 折射率: 1.645

Dihydroxythiobinupharidine英文别名

• 6,6'-dihydroxythiobinupharidine
• Dispiro[2H-quinolizine-3(4H),2'(3'H)-thiophene-4'(5'H),3''(4''H)-[2H]quinolizine]-4,4''-diol, 6,6''-di-3-furanyldodecahydro-9,9''-dimethyl-, (3S,4R,4'S,4''R,6S,6''S,9R,9''R,9aS,9a''S)-
• (3S,4R,4'S,4''R,6S,6''S,9R,9''R,9aS,9a''S)-6,6''-Di(3-furyl)-9,9''-dimethyldodecahydro-2H,2''H-dispiro[quinolizine-3,2'-thiophene-4',3''-quinolizine]-4,4''-diol
• (3S,4R,4'S,4''R,6S,6''S,9R,9''R,9aS,9a''S)-6,6''-di(furan-3-yl)-9,9''-dimethyldodecahydro-2H,2''H-dispiro[quinolizine-3,2'-thiophene-4',3''-quinolizine]-4,4''-diol
• (+)-6,6'-dihydroxythiobinupharidine