Dihydroxythiobinupharidine

Names

[ Name ]:
Dihydroxythiobinupharidine

[Synonym ]:
6,6'-dihydroxythiobinupharidine
Dispiro[2H-quinolizine-3(4H),2'(3'H)-thiophene-4'(5'H),3''(4''H)-[2H]quinolizine]-4,4''-diol, 6,6''-di-3-furanyldodecahydro-9,9''-dimethyl-, (3S,4R,4'S,4''R,6S,6''S,9R,9''R,9aS,9a''S)-
(3S,4R,4'S,4''R,6S,6''S,9R,9''R,9aS,9a''S)-6,6''-Di(3-furyl)-9,9''-dimethyldodecahydro-2H,2''H-dispiro[quinolizine-3,2'-thiophene-4',3''-quinolizine]-4,4''-diol
(3S,4R,4'S,4''R,6S,6''S,9R,9''R,9aS,9a''S)-6,6''-di(furan-3-yl)-9,9''-dimethyldodecahydro-2H,2''H-dispiro[quinolizine-3,2'-thiophene-4',3''-quinolizine]-4,4''-diol
(+)-6,6'-dihydroxythiobinupharidine

Biological Activity

[Description]:

6,6′-Dihydroxythiobinupharidine is a cysteine proteases inhibitor. 6,6′-Dihydroxythiobinupharidine can enhance DNA cleavage mediated by human topoisomerase IIα and IIβ ~8-fold and ~3-fold, respectively[1][2].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Metabolic Enzyme/Protease >> Cathepsin

[References]

[1]. YamaharaJ, et al. Potent immunosuppressive principles, dimeric sesquiterpenethioalkaloids, isolated from nupharis rhizoma, the rhizoma of Nuphar pumilum(nymphaeaceae): structure-requirement of nuphar-alkaloid for immunosuppressiveactivity. Biol Pharm Bull. 1996;19(9):1241-1243.

[2]. DalvieED, et al. 6,6'-Dihydroxythiobinupharidine as a poison of human type IItopoisomerases. Bioorg Med Chem Lett. 2019;29(15):1881-1885.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
667.3±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₃₀H₄₂N₂O₄S

[ Molecular Weight ]:
526.73

[ Flash Point ]:
357.4±31.5 °C

[ Exact Mass ]:
526.286499

[ LogP ]:
4.57

[ Vapour Pressure ]:
0.0±2.1 mmHg at 25°C

[ Index of Refraction ]:
1.645

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.