30343-70-5

30343-70-5 structure

Name: Dihydroxythiobinupharidine
Chemical Name: (+)-6,6'-dihydroxythiobinupharidine
CAS Number: 30343-70-5
Molecular Formula: C₃₀H₄₂N₂O₄S
Molecular Weight: 526.73
Catalog: Signaling Pathways Metabolic Enzyme/Protease Cathepsin
Create Date: 2021-09-16 18:52:19
Modify Date: 2024-04-05 22:04:02
6,6′-Dihydroxythiobinupharidine is a cysteine proteases inhibitor. 6,6′-Dihydroxythiobinupharidine can enhance DNA cleavage mediated by human topoisomerase IIα and IIβ ~8-fold and ~3-fold, respectively[1][2].

Name	(+)-6,6'-dihydroxythiobinupharidine
Synonyms	6,6'-dihydroxythiobinupharidine Dispiro[2H-quinolizine-3(4H),2'(3'H)-thiophene-4'(5'H),3''(4''H)-[2H]quinolizine]-4,4''-diol, 6,6''-di-3-furanyldodecahydro-9,9''-dimethyl-, (3S,4R,4'S,4''R,6S,6''S,9R,9''R,9aS,9a''S)- (3S,4R,4'S,4''R,6S,6''S,9R,9''R,9aS,9a''S)-6,6''-Di(3-furyl)-9,9''-dimethyldodecahydro-2H,2''H-dispiro[quinolizine-3,2'-thiophene-4',3''-quinolizine]-4,4''-diol (3S,4R,4'S,4''R,6S,6''S,9R,9''R,9aS,9a''S)-6,6''-di(furan-3-yl)-9,9''-dimethyldodecahydro-2H,2''H-dispiro[quinolizine-3,2'-thiophene-4',3''-quinolizine]-4,4''-diol (+)-6,6'-dihydroxythiobinupharidine

Description	6,6′-Dihydroxythiobinupharidine is a cysteine proteases inhibitor. 6,6′-Dihydroxythiobinupharidine can enhance DNA cleavage mediated by human topoisomerase IIα and IIβ ~8-fold and ~3-fold, respectively[1][2].
Related Catalog	Research Areas >> Others Signaling Pathways >> Metabolic Enzyme/Protease >> Cathepsin
References	[1]. YamaharaJ, et al. Potent immunosuppressive principles, dimeric sesquiterpenethioalkaloids, isolated from nupharis rhizoma, the rhizoma of Nuphar pumilum(nymphaeaceae): structure-requirement of nuphar-alkaloid for immunosuppressiveactivity. Biol Pharm Bull. 1996;19(9):1241-1243. [2]. DalvieED, et al. 6,6'-Dihydroxythiobinupharidine as a poison of human type IItopoisomerases. Bioorg Med Chem Lett. 2019;29(15):1881-1885.