P7C3

Modify Date: 2024-01-04 07:30:07

P7C3 structure	Common Name	P7C3
	CAS Number	301353-96-8	Molecular Weight	474.188
	Density	1.6±0.1 g/cm3	Boiling Point	656.4±55.0 °C at 760 mmHg
	Molecular Formula	C₂₁H₁₈Br₂N₂O	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	350.8±31.5 °C
	Symbol	GHS05, GHS06	Signal Word	Danger

Use of P7C3

P7C3 is a NAMPT activator. P7C3 can enhance learning and memory in aged rats. Protects newborn neurons in the dentate gyrus by mitigating cell death. In vitro: Administration of active P7C3 chemicals to cells treated with doxorubicin, which induces NAD depletion, led to a rebound in intracellular levels of NAD and concomitant protection from doxorubicin-mediated toxicity. In vivo: P7C3 is orally bioavailable, crosses the blood-brain barrier, and is non-toxic at doses several fold higher than the efficacious dose.An easily administered pro-neurogenic compound. The administration of P7C3 is 10mg/ kg( IP) in rats. Administration of P7C3 to normal mice, as well as npas3-/- mice, enhance survival of neurons subsequent to their birth in the SGZ.

Name	1-anilino-3-(3,6-dibromocarbazol-9-yl)propan-2-ol
Synonym	More Synonyms

Description	P7C3 is a NAMPT activator. P7C3 can enhance learning and memory in aged rats. Protects newborn neurons in the dentate gyrus by mitigating cell death. In vitro: Administration of active P7C3 chemicals to cells treated with doxorubicin, which induces NAD depletion, led to a rebound in intracellular levels of NAD and concomitant protection from doxorubicin-mediated toxicity. In vivo: P7C3 is orally bioavailable, crosses the blood-brain barrier, and is non-toxic at doses several fold higher than the efficacious dose.An easily administered pro-neurogenic compound. The administration of P7C3 is 10mg/ kg( IP) in rats. Administration of P7C3 to normal mice, as well as npas3-/- mice, enhance survival of neurons subsequent to their birth in the SGZ.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Nampt Research Areas >> Neurological Disease
References	[1]. Pieper AA et al. Discovery of a proneurogenic, neuroprotective chemical. Cell. 2010 Jul 9;142(1):39-51. [2]. Wang G et al. P7C3 neuroprotective chemicals function by activating the rate-limiting enzyme in NAD salvage. Cell. 2014 Sep 11;158(6):1324-34. [3]. Pieper AA et al. P7C3 and an unbiased approach to drug discovery for neurodegenerative diseases. Chem Soc Rev. 2014 Oct 7;43(19):6716-26.

Description

Related Catalog

Signaling Pathways >> Metabolic Enzyme/Protease >> Nampt

Research Areas >> Neurological Disease

References

[1]. Pieper AA et al. Discovery of a proneurogenic, neuroprotective chemical. Cell. 2010 Jul 9;142(1):39-51.

[2]. Wang G et al. P7C3 neuroprotective chemicals function by activating the rate-limiting enzyme in NAD salvage. Cell. 2014 Sep 11;158(6):1324-34.

[3]. Pieper AA et al. P7C3 and an unbiased approach to drug discovery for neurodegenerative diseases. Chem Soc Rev. 2014 Oct 7;43(19):6716-26.

Density	1.6±0.1 g/cm3
Boiling Point	656.4±55.0 °C at 760 mmHg
Molecular Formula	C₂₁H₁₈Br₂N₂O
Molecular Weight	474.188
Flash Point	350.8±31.5 °C
Exact Mass	471.978577
PSA	37.19000
LogP	6.60
Appearance of Characters	white solid
Vapour Pressure	0.0±2.1 mmHg at 25°C
Index of Refraction	1.687
Storage condition	-20℃

P7C3 MSDS(Chinese)

Symbol	GHS05, GHS06
Signal Word	Danger
Hazard Statements	H301-H318
Precautionary Statements	P280-P301 + P310-P305 + P351 + P338
RIDADR	UN 2811 6.1 / PGIII
HS Code	2933990090

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Chronic P7C3 treatment restores hippocampal neurogenesis in the Ts65Dn mouse model of Down Syndrome [Corrected].

Neurosci. Lett. 591 , 86-92, (2015)

Down syndrome (DS) is the most common genetic cause of intellectual disability and developmental delay. In addition to cognitive dysfunction, DS patients are marked by diminished neurogenesis, a neuro...

Contribution of growth differentiation factor 6-dependent cell survival to early-onset retinal dystrophies.

Hum. Mol. Genet. 22(7) , 1432-42, (2013)

Retinal dystrophies are predominantly caused by mutations affecting the visual phototransduction system and cilia, with few genes identified that function to maintain photoreceptor survival. We reason...

Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of amyotrophic lateral sclerosis.

Proc. Natl. Acad. Sci. U. S. A. 109(42) , 17016-21, (2012)

We previously reported the discovery of P7C3, an aminopropyl carbazole having proneurogenic and neuroprotective properties in newborn neural precursor cells of the hippocampal dentate gyrus. We have f...

P7C3

1-(3,6-Dibromo-carbazol-9-yl)-3-phenylamino-propan-2-ol

1-Anilino-3-(3,6-dibromo-9H-carbazol-9-yl)-2-propanol

9H-Carbazole-9-ethanol, 3,6-dibromo-α-[(phenylamino)methyl]-

1-(3,6-dibromo-9H-carbazol-9-yl)-3-(phenylamino)propan-2-ol

1-Anilino-3-(3,6-dibromo-9H-carbazol-9-yl)propan-2-ol

DC Chemicals Limited
China
Product Name: P7C3
Price: $375.0/100mg $750.0/250mg $1500.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Get all suppliers and price by the below link:

P7C3 suppliers

Price: $66/10mM*1mLinDMSO

Reference only. check more P7C3 price

P7C3

Use of P7C3

Names

P7C3 Biological Activity

Chemical & Physical Properties

MSDS

Safety Information

Customs

Articles4

Synonyms