301353-96-8

301353-96-8 structure

Name: P7C3
Chemical Name: 1-anilino-3-(3,6-dibromocarbazol-9-yl)propan-2-ol
CAS Number: 301353-96-8
Molecular Formula: C₂₁H₁₈Br₂N₂O
Molecular Weight: 474.188
Catalog: Signaling Pathways Metabolic Enzyme/Protease Nampt
Create Date: 2016-04-19 05:38:53
Modify Date: 2024-01-04 07:30:07
P7C3 is a NAMPT activator. P7C3 can enhance learning and memory in aged rats. Protects newborn neurons in the dentate gyrus by mitigating cell death. In vitro: Administration of active P7C3 chemicals to cells treated with doxorubicin, which induces NAD depletion, led to a rebound in intracellular levels of NAD and concomitant protection from doxorubicin-mediated toxicity. In vivo: P7C3 is orally bioavailable, crosses the blood-brain barrier, and is non-toxic at doses several fold higher than the efficacious dose.An easily administered pro-neurogenic compound. The administration of P7C3 is 10mg/ kg( IP) in rats. Administration of P7C3 to normal mice, as well as npas3-/- mice, enhance survival of neurons subsequent to their birth in the SGZ.

Name	1-anilino-3-(3,6-dibromocarbazol-9-yl)propan-2-ol
Synonyms	P7C3 1-(3,6-Dibromo-carbazol-9-yl)-3-phenylamino-propan-2-ol 1-Anilino-3-(3,6-dibromo-9H-carbazol-9-yl)-2-propanol 9H-Carbazole-9-ethanol, 3,6-dibromo-α-[(phenylamino)methyl]- 1-(3,6-dibromo-9H-carbazol-9-yl)-3-(phenylamino)propan-2-ol 1-Anilino-3-(3,6-dibromo-9H-carbazol-9-yl)propan-2-ol

Description	P7C3 is a NAMPT activator. P7C3 can enhance learning and memory in aged rats. Protects newborn neurons in the dentate gyrus by mitigating cell death. In vitro: Administration of active P7C3 chemicals to cells treated with doxorubicin, which induces NAD depletion, led to a rebound in intracellular levels of NAD and concomitant protection from doxorubicin-mediated toxicity. In vivo: P7C3 is orally bioavailable, crosses the blood-brain barrier, and is non-toxic at doses several fold higher than the efficacious dose.An easily administered pro-neurogenic compound. The administration of P7C3 is 10mg/ kg( IP) in rats. Administration of P7C3 to normal mice, as well as npas3-/- mice, enhance survival of neurons subsequent to their birth in the SGZ.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Nampt Research Areas >> Neurological Disease
References	[1]. Pieper AA et al. Discovery of a proneurogenic, neuroprotective chemical. Cell. 2010 Jul 9;142(1):39-51. [2]. Wang G et al. P7C3 neuroprotective chemicals function by activating the rate-limiting enzyme in NAD salvage. Cell. 2014 Sep 11;158(6):1324-34. [3]. Pieper AA et al. P7C3 and an unbiased approach to drug discovery for neurodegenerative diseases. Chem Soc Rev. 2014 Oct 7;43(19):6716-26.

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%