P7C3

Names

[ Name ]:
P7C3

[Synonym ]:
P7C3
1-(3,6-Dibromo-carbazol-9-yl)-3-phenylamino-propan-2-ol
1-Anilino-3-(3,6-dibromo-9H-carbazol-9-yl)-2-propanol
9H-Carbazole-9-ethanol, 3,6-dibromo-α-[(phenylamino)methyl]-
1-(3,6-dibromo-9H-carbazol-9-yl)-3-(phenylamino)propan-2-ol
1-Anilino-3-(3,6-dibromo-9H-carbazol-9-yl)propan-2-ol

Biological Activity

[Description]:

P7C3 is a NAMPT activator. P7C3 can enhance learning and memory in aged rats. Protects newborn neurons in the dentate gyrus by mitigating cell death. In vitro: Administration of active P7C3 chemicals to cells treated with doxorubicin, which induces NAD depletion, led to a rebound in intracellular levels of NAD and concomitant protection from doxorubicin-mediated toxicity. In vivo: P7C3 is orally bioavailable, crosses the blood-brain barrier, and is non-toxic at doses several fold higher than the efficacious dose.An easily administered pro-neurogenic compound. The administration of P7C3 is 10mg/ kg( IP) in rats. Administration of P7C3 to normal mice, as well as npas3-/- mice, enhance survival of neurons subsequent to their birth in the SGZ.

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Nampt

Research Areas >> Neurological Disease

[References]

[1]. Pieper AA et al. Discovery of a proneurogenic, neuroprotective chemical. Cell. 2010 Jul 9;142(1):39-51.

[2]. Wang G et al. P7C3 neuroprotective chemicals function by activating the rate-limiting enzyme in NAD salvage. Cell. 2014 Sep 11;158(6):1324-34.

[3]. Pieper AA et al. P7C3 and an unbiased approach to drug discovery for neurodegenerative diseases. Chem Soc Rev. 2014 Oct 7;43(19):6716-26.

[Related Small Molecules]

FK866 (APO866, Daporinad) | STF 118804 | GMX1778 | KPT-9274 | GNE-617 | Nampt-IN-1 | CB 300919 | CB30865

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
656.4±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₁H₁₈Br₂N₂O

[ Molecular Weight ]:
474.188

[ Flash Point ]:
350.8±31.5 °C

[ Exact Mass ]:
471.978577

[ PSA ]:
37.19000

[ LogP ]:
6.60

[ Appearance of Characters ]:
white solid

[ Vapour Pressure ]:
0.0±2.1 mmHg at 25°C

[ Index of Refraction ]:
1.687

[ Storage condition ]:
-20℃

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS05, GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H318

[ Precautionary Statements ]:
P280-P301 + P310-P305 + P351 + P338

[ RIDADR ]:
UN 2811 6.1 / PGIII

[ HS Code ]:
2933990090

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Chronic P7C3 treatment restores hippocampal neurogenesis in the Ts65Dn mouse model of Down Syndrome [Corrected].

Neurosci. Lett. 591 , 86-92, (2015)

Down syndrome (DS) is the most common genetic cause of intellectual disability and developmental delay. In addition to cognitive dysfunction, DS patients are marked by diminished neurogenesis, a neuro...

Contribution of growth differentiation factor 6-dependent cell survival to early-onset retinal dystrophies.

Hum. Mol. Genet. 22(7) , 1432-42, (2013)

Retinal dystrophies are predominantly caused by mutations affecting the visual phototransduction system and cilia, with few genes identified that function to maintain photoreceptor survival. We reason...

Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of amyotrophic lateral sclerosis.

Proc. Natl. Acad. Sci. U. S. A. 109(42) , 17016-21, (2012)

We previously reported the discovery of P7C3, an aminopropyl carbazole having proneurogenic and neuroprotective properties in newborn neural precursor cells of the hippocampal dentate gyrus. We have f...