Tianeptine Sodium Salt

Modify Date: 2024-01-02 19:15:27

Tianeptine Sodium Salt structure	Common Name	Tianeptine Sodium Salt
	CAS Number	30123-17-2	Molecular Weight	458.934
	Density	1.38 g/cm3	Boiling Point	609.2ºC at 760 mmHg
	Molecular Formula	C₂₁H₂₄ClN₂NaO₄S	Melting Point	1800C
	MSDS	Chinese USA	Flash Point	322.2ºC

Use of Tianeptine Sodium Salt

Tianeptine sodium salt is a selective facilitator of 5-HT uptake in vitro and in vivo. IC50 Value:Target: 5-HT ReceptorTianeptine has no affinity for a wide range of receptors, including 5-HT and dopamine (IC50 > 10 μM) and has no effect on noradrenalin or dopamine uptake. Antidepressant, analgesic and neuroprotective following systemic administration in vivo.

Name	Tianeptine sodium salt hydrate
Synonym	More Synonyms

Description	Tianeptine sodium salt is a selective facilitator of 5-HT uptake in vitro and in vivo. IC50 Value:Target: 5-HT ReceptorTianeptine has no affinity for a wide range of receptors, including 5-HT and dopamine (IC50 > 10 μM) and has no effect on noradrenalin or dopamine uptake. Antidepressant, analgesic and neuroprotective following systemic administration in vivo.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor Research Areas >> Neurological Disease
References	[1]. Broqua P; Baudrie V; Chaouloff F Differential effects of the novel antidepressant tianeptine on L-5-hydroxytryptophan (5-HTP)-elicited corticosterone release and body weight loss. Eur Neuropsychopharmacol. 1992 Jun;2(2):115-20. [2]. Orescanin-Dusic Z, et al. Tianeptine's effects on spontaneous and Ca2+-induced uterine smooth muscle contraction. Acta Physiol Hung. 2012 Jun;99(2):140-7. [3]. Della FP, Abelaira HM, Réus GZ, Ribeiro KF, Antunes AR, Scaini G, Jeremias IC, Dos Santos LM, Jeremias GC, Streck EL, Quevedo J.Tianeptine treatment induces antidepressive-like effects and alters BDNF and energy metabolism in the brain of rats.Behav Brain Res. 2012 Aug 1;233(2):526-35. Epub 2012 May 31. [4]. Sohn W, Lee OY, Kwon JG, Park KS, Lim YJ, Kim TH, Jung SW, Kim JI.Tianeptine vs amitriptyline for the treatment of irritable bowel syndrome with diarrhea: a multicenter, open-label, non-inferiority, randomized controlled study.Neurogastroenterol Motil. 2012 Sep;24(9):860-e398. [5]. Orola L, Veidis MV, Sarcevica I, Actins A, Belyakov S, Platonenko A.The effect of pH on polymorph formation of the pharmaceutically active compound tianeptine.Int J Pharm. 2012 Aug 1;432(1-2):50-6. Epub 2012 Apr 30.

Description

Related Catalog

Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor

Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor

Research Areas >> Neurological Disease

References

[1]. Broqua P; Baudrie V; Chaouloff F Differential effects of the novel antidepressant tianeptine on L-5-hydroxytryptophan (5-HTP)-elicited corticosterone release and body weight loss. Eur Neuropsychopharmacol. 1992 Jun;2(2):115-20.

[2]. Orescanin-Dusic Z, et al. Tianeptine's effects on spontaneous and Ca2+-induced uterine smooth muscle contraction. Acta Physiol Hung. 2012 Jun;99(2):140-7.

[3]. Della FP, Abelaira HM, Réus GZ, Ribeiro KF, Antunes AR, Scaini G, Jeremias IC, Dos Santos LM, Jeremias GC, Streck EL, Quevedo J.Tianeptine treatment induces antidepressive-like effects and alters BDNF and energy metabolism in the brain of rats.Behav Brain Res. 2012 Aug 1;233(2):526-35. Epub 2012 May 31.

[4]. Sohn W, Lee OY, Kwon JG, Park KS, Lim YJ, Kim TH, Jung SW, Kim JI.Tianeptine vs amitriptyline for the treatment of irritable bowel syndrome with diarrhea: a multicenter, open-label, non-inferiority, randomized controlled study.Neurogastroenterol Motil. 2012 Sep;24(9):860-e398.

[5]. Orola L, Veidis MV, Sarcevica I, Actins A, Belyakov S, Platonenko A.The effect of pH on polymorph formation of the pharmaceutically active compound tianeptine.Int J Pharm. 2012 Aug 1;432(1-2):50-6. Epub 2012 Apr 30.

Density	1.38 g/cm3
Boiling Point	609.2ºC at 760 mmHg
Melting Point	1800C
Molecular Formula	C₂₁H₂₄ClN₂NaO₄S
Molecular Weight	458.934
Flash Point	322.2ºC
Exact Mass	458.104309
PSA	97.92000
LogP	4.39460
Storage condition	Desiccate at RT