BMS-309403

Modify Date: 2024-01-02 15:26:08

BMS-309403 structure	Common Name	BMS-309403
	CAS Number	300657-03-8	Molecular Weight	474.550
	Density	1.2±0.1 g/cm3	Boiling Point	657.5±55.0 °C at 760 mmHg
	Molecular Formula	C₃₁H₂₆N₂O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	351.4±31.5 °C

Use of BMS-309403

BMS-309403 is a potent, selective and cell-permeable inhibitor of fatty acid binding protein 4 (FABP4) with a Ki of less than 2 nM.

Name	2-[3-[2-(5-ethyl-3,4-diphenylpyrazol-1-yl)phenyl]phenoxy]acetic acid
Synonym	More Synonyms

Description	BMS-309403 is a potent, selective and cell-permeable inhibitor of fatty acid binding protein 4 (FABP4) with a Ki of less than 2 nM.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> FABP Research Areas >> Cardiovascular Disease Research Areas >> Metabolic Disease
Target	Ki: less than 2 nM (FABP4), 250 nM (FABP3), 350 nM (FABP5)[1]
In Vitro	BMS-309403 binds to FABP4 with high affinity and shows over 100-fold selectivity against FABP5 as well as the heart isoform FABP3[1]. BMS-309403 interacts with the fatty-acid-binding pocket within the interior of the protein and competitively inhibits the binding of endogenous fatty acids. Treatment with BMS-309403 significantly decreased MCP-1 production from THP-1 macrophages in a dose- and time-dependent manner[2]. BMS-309403 stimulates glucose uptake in C2C12 myotubes in a temporal and dose dependent manner via activation of AMP-activated protein kinase (AMPK) signaling pathway but independent of FABPs[3].
In Vivo	A 6 week treatment with BMS-309403 improves endothelial function, phosphorylated and total eNOS and reduced plasma triglyceride levels but does not affect endothelium-independent relaxations. In cultured human microvascular endothelial cells, lipid-induced A-FABP expression is associated with reduced phosphorylated eNOS and NO production and is reversed by BMS-309403[4]. The extent of atherosclerotic lesion area in the proximal aorta is significantly reduced in the BMS-309403-treated group compared with vehicle-treated controls in both the early and late intervention studies[2].
Animal Admin	Mice: To determine the effects of pharmacological inhibition of the actions of A-FABP, either the A-FABP inhibitor BMS-309403 (15 mg/kg) or vehicle (4% Tween 80) are administered chronically by daily oral gavage for 6 weeks in ApoE−/− mice (starting at weeks 12 of age). Mice are anaesthetized with a bolus injection of pentobarbitone sodium (230 mg/kg) and their aorta removed and dissected for further analysis[4].
References	[1]. Sulsky R, et al. Potent and selective biphenyl azole inhibitors of adipocyte fatty acid binding protein (aFABP). Bioorg Med Chem Lett. 2007 Jun 15;17(12):3511-5. [2]. Furuhashi M, et al. Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2. Nature. 2007 Jun 21;447(7147):959-65. [3]. Lin W, et al. BMS309403 stimulates glucose uptake in myotubes through activation of AMP-activated protein kinase. PLoS One. 2012;7(8):e44570. [4]. Lee MY, et al. Chronic administration of BMS309403 improves endothelial function in apolipoprotein E-deficient mice and in cultured human endothelial cells. Br J Pharmacol. 2011 Apr;162(7):1564-76.

Density	1.2±0.1 g/cm3
Boiling Point	657.5±55.0 °C at 760 mmHg
Molecular Formula	C₃₁H₂₆N₂O₃
Molecular Weight	474.550
Flash Point	351.4±31.5 °C
Exact Mass	474.194336
PSA	64.35000
LogP	7.69
Vapour Pressure	0.0±2.1 mmHg at 25°C
Index of Refraction	1.623

Hazard Codes	Xi

Acetic acid, 2-[[2'-(5-ethyl-3,4-diphenyl-1H-pyrazol-1-yl)[1,1'-biphenyl]-3-yl]oxy]-

{[2'-(5-Ethyl-3,4-diphenyl-1H-pyrazol-1-yl)-3-biphenylyl]oxy}acetic acid

2-[[2'-(5-Ethyl-3,4-diphenyl-1H-pyrazol-1-yl)[1,1'-biphenyl]-3-yl]oxy]acetic acid

UNII-M5X9XSU6J5

T4B

((2'-(5-Ethyl-3,4-Diphenyl-1h-Pyrazol-1-Yl)-3-Biphenylyl)oxy)acetic Acid

cc-561

[2'-(5-Ethyl-3,4-diphenyl-pyrazol-1-yl)-biphenyl-3-yloxy]acetic acid

BMS-309403

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: BMS-309403
Price: ￥2038.0/50mg
Purity: 98.0%
Stocking Period: 2 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: BMS-309403
Price: $480.0/100mg $900.0/250mg $1900.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 2-((2'-(5-ETHYL-3,4-DIPHENYL-1H-PYRAZOL-1-YL)-[1,1'-BIPHENYL]-3-YL)OXY)ACETIC ACID
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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Price: $92/10mM*1mLinDMSO

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BMS-309403

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