Thiazolyl Blue

Modify Date: 2024-01-02 18:39:32

Thiazolyl Blue Structure
Thiazolyl Blue structure
Common Name Thiazolyl Blue
CAS Number 298-93-1 Molecular Weight 414.322
Density N/A Boiling Point N/A
Molecular Formula C18H16BrN5S Melting Point 195 °C (dec.)(lit.)
MSDS Chinese USA Flash Point N/A
Symbol GHS07 GHS08
GHS07, GHS08
Signal Word Warning

 Use of Thiazolyl Blue


MTT is a colorimetric agent widely used to measure cell proliferation. MTT is reduced from yellow color to purple formazan in living cells.

 Names

Name 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide
Synonym More Synonyms

 Thiazolyl Blue Biological Activity

Description MTT is a colorimetric agent widely used to measure cell proliferation. MTT is reduced from yellow color to purple formazan in living cells.
Related Catalog
In Vitro MTT is used in conjunction with rhodamine B to measure mitochondrial membrane potential. MTT-formazan is generated in mitochondria acts as a fluorescence quencher for rhodamine that distributes across membranes of viable cells according to membrane potential. In the absence of mPMS, cellular reduction of MTT is strong. MTT is membrane-impermeable when incorporated into large unilamellar liposomes, and therefore it is taken up by cells via endocytosis[1].
References

[1]. Berridge MV, et al. Tetrazolium dyes as tools in cell biology: new insights into their cellular reduction. Biotechnol Annu Rev. 2005;11:127-52.

 Chemical & Physical Properties

Melting Point 195 °C (dec.)(lit.)
Molecular Formula C18H16BrN5S
Molecular Weight 414.322
Exact Mass 413.030975
PSA 75.72000
LogP 0.28830
Storage condition 2-8°C
Water Solubility Slightly soluble

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
XF8060000
CHEMICAL NAME :
2H-Tetrazolium, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-, bromide
CAS REGISTRY NUMBER :
298-93-1
LAST UPDATED :
199701
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C18-H16-N5-S.Br
MOLECULAR WEIGHT :
414.36
WISWESSER LINE NOTATION :
T5NNKNJ BR& ER& C- BT5N CSJ D1 E1 &E

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :
Mutation in microorganisms
TEST SYSTEM :
Bacteria - Escherichia coli
DOSE/DURATION :
5 ug/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 68,107,1979 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1328 No. of Facilities: 93 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 1106 (estimated) No. of Female Employees: 985 (estimated)

 Safety Information

Symbol GHS07 GHS08
GHS07, GHS08
Signal Word Warning
Hazard Statements H315-H319-H335-H341
Precautionary Statements P261-P281-P305 + P351 + P338
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi: Irritant;
Risk Phrases R46
Safety Phrases S22-S24/25
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS XF8060000
HS Code 29341000

 Customs

HS Code 29341000

 Articles3106

More Articles
Neuroprotective effect of modified Chungsimyeolda-tang, a traditional Korean herbal formula, via autophagy induction in models of Parkinson's disease.

J. Ethnopharmacol. 159 , 93-101, (2014)

Previous studies in our laboratory revealed the neuroprotective effect of modified Yeoldahanso-tang (MYH) in models of Parkinson׳s disease (PD). In this study, we investigated another traditional Kore...

Pro-apoptotic and pro-autophagic effects of the Aurora kinase A inhibitor alisertib (MLN8237) on human osteosarcoma U-2 OS and MG-63 cells through the activation of mitochondria-mediated pathway and inhibition of p38 MAPK/PI3K/Akt/mTOR signaling pathway.

Drug Des. Devel. Ther. 9 , 1555-84, (2015)

Osteosarcoma (OS) is the most common malignant bone tumor occurring mostly in children and adolescents between 10 and 20 years of age with poor response to current therapeutics. Alisertib (ALS, MLN823...

Alisertib, an Aurora kinase A inhibitor, induces apoptosis and autophagy but inhibits epithelial to mesenchymal transition in human epithelial ovarian cancer cells.

Drug Des. Devel. Ther. 9 , 425-64, (2015)

Ovarian cancer is a leading killer of women, and no cure for advanced ovarian cancer is available. Alisertib (ALS), a selective Aurora kinase A (AURKA) inhibitor, has shown potent anticancer effects, ...

 Synonyms

3-(4,5-Dimethyl-2-thiazolyl)-2,5-diphenyltetrazolium Bromide
ThiazolylBlue(Mtt)
MttA.R.
2H-Tetrazolium, 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-, bromide (1:1)
3-(4,5-Dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium Bromide
3-(4,5-Dimethyl-1,3-thiazol-2-yl)-2,5-diphenyl-2H-tetrazol-3-ium bromide
Methylthiazoletetrazolium bromide
Thiazolyl Blue
2H-tetrazolium, 2-(4,5-dimethyl-2-thiazolyl)-3,5-diphenyl-, bromide (1:1)
2-(4,5-Dimethyl-1,3-thiazol-2-yl)-3,5-diphenyl-2H-tetrazol-3-ium bromide
MFCD00011964
EINECS 206-069-5
THIAZOLE BLUE
Thiazolyl blue tetrazolium bromide (MTT)
thiazolyl blue tetrazolium bromide
mmttetrazolium
3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyl-2H-Tetrazolium Bromide
MTT
Top Suppliers:I want be here





Get all suppliers and price by the below link:

Thiazolyl Blue suppliers


Price: $106/10mM*1mLinDMSO

Reference only. check more Thiazolyl Blue price