MAO A/HSP90-IN-1

Modify Date: 2025-08-21 21:13:46

MAO A/HSP90-IN-1 structure	Common Name	MAO A/HSP90-IN-1
	CAS Number	2927489-95-8	Molecular Weight	444.95
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₄H₂₉ClN₂O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of MAO A/HSP90-IN-1

MAO A/HSP90-IN-1 (4-b) is a MAO A/HSP90 dual inhibitor with IC50 value of 1.77 μM and 0.019 μM in Glioblastoma (GBM) GL26 cells and HSP90α, respectively. MAO A/HSP90-IN-1 (4-b) can inhibit MAO A activity, HSP90 binding and the expression of HER2 and phospho-Akt to inhibit the growth of GBM, they also reduce PD-L1 expression, which inhibits T cell activation. MAO A/HSP90-IN-1 (4-b) have potential to inhibit tumor immune escape. MAO A/HSP90-IN-1 (4-b) can be used for brain tumor-related diseases research[1].

Name	MAO A/HSP90-IN-1

Description	MAO A/HSP90-IN-1 (4-b) is a MAO A/HSP90 dual inhibitor with IC50 value of 1.77 μM and 0.019 μM in Glioblastoma (GBM) GL26 cells and HSP90α, respectively. MAO A/HSP90-IN-1 (4-b) can inhibit MAO A activity, HSP90 binding and the expression of HER2 and phospho-Akt to inhibit the growth of GBM, they also reduce PD-L1 expression, which inhibits T cell activation. MAO A/HSP90-IN-1 (4-b) have potential to inhibit tumor immune escape. MAO A/HSP90-IN-1 (4-b) can be used for brain tumor-related diseases research[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> HSP Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase Signaling Pathways >> Cell Cycle/DNA Damage >> HSP
Target	HSP90:0.019 μM (IC50) MAO-A:1.77 μM (IC50)
References	[1]. Tseng HJ, et al. Design, synthesis, and biological activity of dual monoamine oxidase A and heat shock protein 90 inhibitors, N-Methylpropargylamine-conjugated 4-isopropylresorcinol for glioblastoma. Eur J Med Chem. 2023 Aug 5;256:115459.

Molecular Formula	C₂₄H₂₉ClN₂O₄
Molecular Weight	444.95
InChIKey	JHKZNXCXUMFEOS-UHFFFAOYSA-N
SMILES	C#CCN(C)CCCOc1ccc(N(C)C(=O)c2cc(C(C)C)c(O)cc2O)cc1Cl

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MAO A/HSP90-IN-1

Use of MAO A/HSP90-IN-1

Names

MAO A/HSP90-IN-1 Biological Activity

Chemical & Physical Properties

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.