2927489-95-8

2927489-95-8 structure

Name: MAO A/HSP90-IN-1
Chemical Name: MAO A/HSP90-IN-1
CAS Number: 2927489-95-8
Molecular Formula: C₂₄H₂₉ClN₂O₄
Molecular Weight: 444.95
Catalog: Signaling Pathways Cell Cycle/DNA Damage HSP
Create Date: 2023-10-03 06:58:26
Modify Date: 2024-01-05 12:04:11
MAO A/HSP90-IN-1 (4-b) is a MAO A/HSP90 dual inhibitor with IC50 value of 1.77 μM and 0.019 μM in Glioblastoma (GBM) GL26 cells and HSP90α, respectively. MAO A/HSP90-IN-1 (4-b) can inhibit MAO A activity, HSP90 binding and the expression of HER2 and phospho-Akt to inhibit the growth of GBM, they also reduce PD-L1 expression, which inhibits T cell activation. MAO A/HSP90-IN-1 (4-b) have potential to inhibit tumor immune escape. MAO A/HSP90-IN-1 (4-b) can be used for brain tumor-related diseases research[1].

Name	MAO A/HSP90-IN-1

Description	MAO A/HSP90-IN-1 (4-b) is a MAO A/HSP90 dual inhibitor with IC50 value of 1.77 μM and 0.019 μM in Glioblastoma (GBM) GL26 cells and HSP90α, respectively. MAO A/HSP90-IN-1 (4-b) can inhibit MAO A activity, HSP90 binding and the expression of HER2 and phospho-Akt to inhibit the growth of GBM, they also reduce PD-L1 expression, which inhibits T cell activation. MAO A/HSP90-IN-1 (4-b) have potential to inhibit tumor immune escape. MAO A/HSP90-IN-1 (4-b) can be used for brain tumor-related diseases research[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> HSP Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase Signaling Pathways >> Cell Cycle/DNA Damage >> HSP
Target	HSP90:0.019 μM (IC50) MAO-A:1.77 μM (IC50)
References	[1]. Tseng HJ, et al. Design, synthesis, and biological activity of dual monoamine oxidase A and heat shock protein 90 inhibitors, N-Methylpropargylamine-conjugated 4-isopropylresorcinol for glioblastoma. Eur J Med Chem. 2023 Aug 5;256:115459.

Molecular Formula	C₂₄H₂₉ClN₂O₄
Molecular Weight	444.95