2-Thiothymidine

Modify Date: 2024-01-11 01:02:05

2-Thiothymidine Structure
2-Thiothymidine structure
Common Name 2-Thiothymidine
CAS Number 28585-51-5 Molecular Weight 258.29
Density 1.52 g/cm3 Boiling Point N/A
Molecular Formula C10H14N2O4S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of 2-Thiothymidine


2-Thiothymidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

 Names

Name 1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-2-sulfanylidenepyrimidin-4-one
Synonym More Synonyms

 2-Thiothymidine Biological Activity

Description 2-Thiothymidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Related Catalog
References

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

 Chemical & Physical Properties

Density 1.52 g/cm3
Molecular Formula C10H14N2O4S
Molecular Weight 258.29
Exact Mass 258.06700
PSA 119.57000
Index of Refraction 1.672

 Synthetic Route

~%

2-Thiothymidine Structure

2-Thiothymidine

CAS#:28585-51-5

Literature: Hatano, Akihiko; Kurosu, Masayuki; Yonaha, Susumu; Okada, Munehiro; Uehara, Sanae Organic and Biomolecular Chemistry, 2013 , vol. 11, # 40 p. 6900 - 6905

~59%

2-Thiothymidine Structure

2-Thiothymidine

CAS#:28585-51-5

Literature: Hatano, Akihiko; Harano, Aiko; Kirihara, Masayuki Chemistry Letters, 2006 , vol. 35, # 2 p. 232 - 233

 Precursor & DownStream

Precursor  2

DownStream  0

 Synonyms

Thymidine,2-thio
2-Thiothymidin
2-thiothymidine
2-Thio-desoxythymidin