2-Thiothymidine

Names

[ Name ]:
2-Thiothymidine

[Synonym ]:
Thymidine,2-thio
2-Thiothymidin
2-thiothymidine
2-Thio-desoxythymidin

Biological Activity

[Description]:

2-Thiothymidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

Chemical & Physical Properties

[ Density]:
1.52 g/cm3

[ Molecular Formula ]:
C₁₀H₁₄N₂O₄S

[ Molecular Weight ]:
258.29

[ Exact Mass ]:
258.06700

[ PSA ]:
119.57000

[ Index of Refraction ]:
1.672

2-Thiothymidine

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds