JNJ-6204

Modify Date: 2024-01-11 22:46:45

JNJ-6204 structure	Common Name	JNJ-6204
	CAS Number	2765264-50-2	Molecular Weight	370.41
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₉H₁₁D₆FN₆O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of JNJ-6204

JNJ-6204 is a dual inhibitor for CSNK1D (Casein Kinase 1 Delta) and CSNK1E (Casein Kinase 1 Epsilon) (CSNK1D IC50=2.3 nM; CSNK1E IC50=137 nM). JNJ-6204 shows good brain exposure[1][2].

Name	JNJ-6204

Description	JNJ-6204 is a dual inhibitor for CSNK1D (Casein Kinase 1 Delta) and CSNK1E (Casein Kinase 1 Epsilon) (CSNK1D IC50=2.3 nM; CSNK1E IC50=137 nM). JNJ-6204 shows good brain exposure[1][2].
Related Catalog	Research Areas >> Others Signaling Pathways >> Cell Cycle/DNA Damage >> Casein Kinase Signaling Pathways >> Stem Cell/Wnt >> Casein Kinase
Target	IC50: 2.3 nM (CSNK1D)[2]
In Vitro	JNJ-6204 inhibits CSNK1D in the BRET whole cell binding assay and in the PER2 translocation whole cell functional assay with IC50s of 72 nM and 542 nM, respectively[2].
References	[1]. Terry Patrick LEBOLD, et al. Casein kinase 1 delta modulators. WO2022058920A1. [2]. https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/JNJ-6204

Molecular Formula	C₁₉H₁₁D₆FN₆O
Molecular Weight	370.41