2765264-50-2
2765264-50-2 structure
- Name: JNJ-6204
- Chemical Name: JNJ-6204
- CAS Number: 2765264-50-2
- Molecular Formula: C19H11D6FN6O
- Molecular Weight: 370.41
- Catalog: Signaling Pathways Cell Cycle/DNA Damage Casein Kinase
- Create Date: 2022-11-21 20:36:23
- Modify Date: 2024-01-11 22:46:45
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JNJ-6204 is a dual inhibitor for CSNK1D (Casein Kinase 1 Delta) and CSNK1E (Casein Kinase 1 Epsilon) (CSNK1D IC50=2.3 nM; CSNK1E IC50=137 nM). JNJ-6204 shows good brain exposure[1][2].
| Name | JNJ-6204 |
|---|
| Description | JNJ-6204 is a dual inhibitor for CSNK1D (Casein Kinase 1 Delta) and CSNK1E (Casein Kinase 1 Epsilon) (CSNK1D IC50=2.3 nM; CSNK1E IC50=137 nM). JNJ-6204 shows good brain exposure[1][2]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 2.3 nM (CSNK1D)[2] |
| In Vitro | JNJ-6204 inhibits CSNK1D in the BRET whole cell binding assay and in the PER2 translocation whole cell functional assay with IC50s of 72 nM and 542 nM, respectively[2]. |
| References |
[1]. Terry Patrick LEBOLD, et al. Casein kinase 1 delta modulators. WO2022058920A1. [2]. https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/JNJ-6204 |
| Molecular Formula | C19H11D6FN6O |
|---|---|
| Molecular Weight | 370.41 |