JNJ-6204

Names

[ CAS No. ]:
2765264-50-2

[ Name ]:
JNJ-6204

Biological Activity

[Description]:

JNJ-6204 is a dual inhibitor for CSNK1D (Casein Kinase 1 Delta) and CSNK1E (Casein Kinase 1 Epsilon) (CSNK1D IC50=2.3 nM; CSNK1E IC50=137 nM). JNJ-6204 shows good brain exposure[1][2].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Cell Cycle/DNA Damage >> Casein Kinase
Signaling Pathways >> Stem Cell/Wnt >> Casein Kinase

[Target]

IC50: 2.3 nM (CSNK1D)[2]


[In Vitro]

JNJ-6204 inhibits CSNK1D in the BRET whole cell binding assay and in the PER2 translocation whole cell functional assay with IC50s of 72 nM and 542 nM, respectively[2].

[References]

[1]. Terry Patrick LEBOLD, et al. Casein kinase 1 delta modulators. WO2022058920A1.

[2]. https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/JNJ-6204

Chemical & Physical Properties

[ Molecular Formula ]:
C19H11D6FN6O

[ Molecular Weight ]:
370.41

Related Compounds