Thio-ITP

Modify Date: 2025-08-25 18:51:58

Use of Thio-ITP

Thio-ITP (6-Thioinosine 5′-triphosphate) is a RNA polymerase activities competitive inhibitor[1].

Name	Inosine 5'-(tetrahydrogen triphosphate), 6-thio
Synonym	More Synonyms

Description	Thio-ITP (6-Thioinosine 5′-triphosphate) is a RNA polymerase activities competitive inhibitor[1].
Related Catalog	Research Areas >> Cancer Research Areas >> Cardiovascular Disease Research Areas >> Endocrinology Research Areas >> Infection Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis Research Areas >> Others Research Areas >> Inflammation/Immunology Research Areas >> Metabolic Disease Research Areas >> Neurological Disease
In Vitro	Thio-ITP inhibits both endogenous and exogenous DNA-directed RNA synthesis[1]. Thio-ITP has a Ki values whit 40.9±11.0 μM, 38.0±6.47 μM of polymerase I and polymerase II, respectively[1].
References	[1]. [1] Kawahata RT, Chuang LF, Holmberg CA, Osburn BI, Chuang RY. Inhibition of human lymphoma DNA-dependent RNA polymerase activity by 6-mercaptopurine ribonucleoside triphosphate. Cancer Res. 1983 Aug;43(8):3655-9.

Density	2.56g/cm3
Boiling Point	981.2ºC at 760 mmHg
Molecular Formula	C₁₀H₁₅N₄O₁₃P₃S
Molecular Weight	524.23
Flash Point	547.2ºC
Exact Mass	523.95700
PSA	317.53000
Vapour Pressure	0mmHg at 25°C
Index of Refraction	1.902
InChIKey	GQNRDWAOABGWGP-KQYNXXCUSA-N
SMILES	O=P(O)(O)OP(=O)(O)OP(=O)(O)OCC1OC(n2cnc3c(=S)nc[nH]c32)C(O)C1O

CHEMICAL NAME :: 9H-Purine-6(1H)-thione, 9-beta-D-ribofuranosyl-, 5'-tetrahydrogen triphosphate

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 43,3655,1983

O5'-tetrahydroxytriphosphoryl-6-thio-inosine

6-thioinosine-5'-triphosphate

6-Thioinosin-5'-triphosphat

6-Mercaptopurin-ribosid-5'-triphosphat

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