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Thio-ITP

Names

[ CAS No. ]:
27652-34-2

[ Name ]:
Thio-ITP

[Synonym ]:
O5'-tetrahydroxytriphosphoryl-6-thio-inosine
6-thioinosine-5'-triphosphate
6-Thioinosin-5'-triphosphat
6-Mercaptopurin-ribosid-5'-triphosphat

Biological Activity

[Description]:

Thio-ITP (6-Thioinosine 5′-triphosphate) is a RNA polymerase activities competitive inhibitor[1].

[Related Catalog]:

Research Areas >> Cancer
Research Areas >> Cardiovascular Disease
Research Areas >> Endocrinology
Research Areas >> Infection
Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis
Research Areas >> Others
Research Areas >> Inflammation/Immunology
Research Areas >> Metabolic Disease
Research Areas >> Neurological Disease

[In Vitro]

Thio-ITP inhibits both endogenous and exogenous DNA-directed RNA synthesis[1]. Thio-ITP has a Ki values whit 40.9±11.0 μM, 38.0±6.47 μM of polymerase I and polymerase II, respectively[1].

[References]

[1]. [1] Kawahata RT, Chuang LF, Holmberg CA, Osburn BI, Chuang RY. Inhibition of human lymphoma DNA-dependent RNA polymerase activity by 6-mercaptopurine ribonucleoside triphosphate. Cancer Res. 1983 Aug;43(8):3655-9.

Chemical & Physical Properties

[ Density]:
2.56g/cm3

[ Boiling Point ]:
981.2ºC at 760 mmHg

[ Molecular Formula ]:
C10H15N4O13P3S

[ Molecular Weight ]:
524.23

[ Flash Point ]:
547.2ºC

[ Exact Mass ]:
523.95700

[ PSA ]:
317.53000

[ Vapour Pressure ]:
0mmHg at 25°C

[ Index of Refraction ]:
1.902

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UP0766000
CHEMICAL NAME :
9H-Purine-6(1H)-thione, 9-beta-D-ribofuranosyl-, 5'-tetrahydrogen triphosphate
CAS REGISTRY NUMBER :
27652-34-2
LAST UPDATED :
198909
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C10-H15-N4-O13-P3-S
MOLECULAR WEIGHT :
524.26

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :
Mutation test systems - not otherwise specified
TEST SYSTEM :
Human Lymphocyte
DOSE/DURATION :
500 umol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 43,3655,1983

Related Compounds

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