Thio-ITP

Names

[ Name ]:
Thio-ITP

[Synonym ]:
O5'-tetrahydroxytriphosphoryl-6-thio-inosine
6-thioinosine-5'-triphosphate
6-Thioinosin-5'-triphosphat
6-Mercaptopurin-ribosid-5'-triphosphat

Biological Activity

[Description]:

Thio-ITP (6-Thioinosine 5′-triphosphate) is a RNA polymerase activities competitive inhibitor[1].

[Related Catalog]:

Research Areas >> Cancer

Research Areas >> Cardiovascular Disease

Research Areas >> Endocrinology

Research Areas >> Infection

Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis

Research Areas >> Others

Research Areas >> Inflammation/Immunology

Research Areas >> Metabolic Disease

Research Areas >> Neurological Disease

[In Vitro]

Thio-ITP inhibits both endogenous and exogenous DNA-directed RNA synthesis[1]. Thio-ITP has a Ki values whit 40.9±11.0 μM, 38.0±6.47 μM of polymerase I and polymerase II, respectively[1].

[References]

[1]. [1] Kawahata RT, Chuang LF, Holmberg CA, Osburn BI, Chuang RY. Inhibition of human lymphoma DNA-dependent RNA polymerase activity by 6-mercaptopurine ribonucleoside triphosphate. Cancer Res. 1983 Aug;43(8):3655-9.

Chemical & Physical Properties

[ Density]:
2.56g/cm3

[ Boiling Point ]:
981.2ºC at 760 mmHg

[ Molecular Formula ]:
C₁₀H₁₅N₄O₁₃P₃S

[ Molecular Weight ]:
524.23

[ Flash Point ]:
547.2ºC

[ Exact Mass ]:
523.95700

[ PSA ]:
317.53000

[ Vapour Pressure ]:
0mmHg at 25°C

[ Index of Refraction ]:
1.902

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UP0766000

CHEMICAL NAME :: 9H-Purine-6(1H)-thione, 9-beta-D-ribofuranosyl-, 5'-tetrahydrogen triphosphate

CAS REGISTRY NUMBER :: 27652-34-2

LAST UPDATED :: 198909

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C10-H15-N4-O13-P3-S

MOLECULAR WEIGHT :: 524.26

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Human Lymphocyte

DOSE/DURATION :: 500 umol/L

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 43,3655,1983