Nebicapone
Modify Date: 2024-01-20 17:48:48
Nebicapone structure
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Common Name | Nebicapone | ||
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| CAS Number | 274925-86-9 | Molecular Weight | 273.24100 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C14H11NO5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of NebicaponeNebicapone (BIA 3-202), a reversible catechol-O-methyltransferase (COMT) inhibitor, is mainly metabolized by glucuronidation. Nebicapone is mainly peripherally acting inhibitor that decreases the biotransformation of L-DOPA to 3-O-methyl-DOPA by inhibition of COMT, and it is potential for the treatment of Parkinson's disease.[1]. |
| Name | 1-(3,4-dihydroxy-5-nitrophenyl)-2-phenylethanone |
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| Synonym | More Synonyms |
| Description | Nebicapone (BIA 3-202), a reversible catechol-O-methyltransferase (COMT) inhibitor, is mainly metabolized by glucuronidation. Nebicapone is mainly peripherally acting inhibitor that decreases the biotransformation of L-DOPA to 3-O-methyl-DOPA by inhibition of COMT, and it is potential for the treatment of Parkinson's disease.[1]. |
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| Related Catalog | |
| References |
| Molecular Formula | C14H11NO5 |
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| Molecular Weight | 273.24100 |
| Exact Mass | 273.06400 |
| PSA | 103.35000 |
| LogP | 2.95460 |
| Hazard Codes | Xi |
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Nebicapone CAS#:274925-86-9 |
| Literature: Learmonth, David A.; Alves, Paula C. Synthetic Communications, 2002 , vol. 32, # 4 p. 641 - 649 |
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Nebicapone CAS#:274925-86-9 |
| Literature: Learmonth, David A.; Vieira-Coelho, Maria A.; Benes, Jan; Alves, Paula C.; Borges, Nuno; Freitas, Ana P.; Soares-da-Silva, Patricio Journal of Medicinal Chemistry, 2002 , vol. 45, # 3 p. 685 - 695 |
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Nebicapone CAS#:274925-86-9 |
| Literature: Learmonth, David A.; Vieira-Coelho, Maria A.; Benes, Jan; Alves, Paula C.; Borges, Nuno; Freitas, Ana P.; Soares-da-Silva, Patricio Journal of Medicinal Chemistry, 2002 , vol. 45, # 3 p. 685 - 695 |
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Nebicapone CAS#:274925-86-9 |
| Literature: Learmonth, David A.; Vieira-Coelho, Maria A.; Benes, Jan; Alves, Paula C.; Borges, Nuno; Freitas, Ana P.; Soares-da-Silva, Patricio Journal of Medicinal Chemistry, 2002 , vol. 45, # 3 p. 685 - 695 |
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Nebicapone CAS#:274925-86-9 |
| Literature: Learmonth, David A.; Vieira-Coelho, Maria A.; Benes, Jan; Alves, Paula C.; Borges, Nuno; Freitas, Ana P.; Soares-da-Silva, Patricio Journal of Medicinal Chemistry, 2002 , vol. 45, # 3 p. 685 - 695 |
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Nebicapone CAS#:274925-86-9 |
| Literature: Learmonth, David A.; Vieira-Coelho, Maria A.; Benes, Jan; Alves, Paula C.; Borges, Nuno; Freitas, Ana P.; Soares-da-Silva, Patricio Journal of Medicinal Chemistry, 2002 , vol. 45, # 3 p. 685 - 695 |
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Nebicapone CAS#:274925-86-9 |
| Literature: Learmonth, David A.; Alves, Paula C. Synthetic Communications, 2002 , vol. 32, # 4 p. 641 - 649 |
| 1-(3,4-dihydroxy-5-nitrophenyl)-2-phenyl-ethanone |
| 1-(3,4-dihydroxy-5-nitrophenyl)-2-phenyl-1-ethanone |
| Nebicapone |
| UNII-NM2KXJ990T |
| BIA 3-202 |