274925-86-9
274925-86-9 structure
- Name: Nebicapone
- Chemical Name: 1-(3,4-dihydroxy-5-nitrophenyl)-2-phenylethanone
- CAS Number: 274925-86-9
- Molecular Formula: C14H11NO5
- Molecular Weight: 273.24100
- Catalog: Signaling Pathways Metabolic Enzyme/Protease COMT
- Create Date: 2016-02-20 07:32:23
- Modify Date: 2025-09-15 16:45:18
-
Nebicapone (BIA 3-202), a reversible catechol-O-methyltransferase (COMT) inhibitor, is mainly metabolized by glucuronidation. Nebicapone is mainly peripherally acting inhibitor that decreases the biotransformation of L-DOPA to 3-O-methyl-DOPA by inhibition of COMT, and it is potential for the treatment of Parkinson's disease.[1].
| Name | 1-(3,4-dihydroxy-5-nitrophenyl)-2-phenylethanone |
|---|---|
| Synonyms |
1-(3,4-dihydroxy-5-nitrophenyl)-2-phenyl-ethanone
1-(3,4-dihydroxy-5-nitrophenyl)-2-phenyl-1-ethanone Nebicapone UNII-NM2KXJ990T BIA 3-202 |
| Description | Nebicapone (BIA 3-202), a reversible catechol-O-methyltransferase (COMT) inhibitor, is mainly metabolized by glucuronidation. Nebicapone is mainly peripherally acting inhibitor that decreases the biotransformation of L-DOPA to 3-O-methyl-DOPA by inhibition of COMT, and it is potential for the treatment of Parkinson's disease.[1]. |
|---|---|
| Related Catalog | |
| References |
| Molecular Formula | C14H11NO5 |
|---|---|
| Molecular Weight | 273.24100 |
| Exact Mass | 273.06400 |
| PSA | 103.35000 |
| LogP | 2.95460 |
| Hazard Codes | Xi |
|---|
|
~99%
274925-86-9 |
| Literature: Learmonth, David A.; Alves, Paula C. Synthetic Communications, 2002 , vol. 32, # 4 p. 641 - 649 |
|
~%
274925-86-9 |
| Literature: Learmonth, David A.; Vieira-Coelho, Maria A.; Benes, Jan; Alves, Paula C.; Borges, Nuno; Freitas, Ana P.; Soares-da-Silva, Patricio Journal of Medicinal Chemistry, 2002 , vol. 45, # 3 p. 685 - 695 |
|
~%
274925-86-9 |
| Literature: Learmonth, David A.; Vieira-Coelho, Maria A.; Benes, Jan; Alves, Paula C.; Borges, Nuno; Freitas, Ana P.; Soares-da-Silva, Patricio Journal of Medicinal Chemistry, 2002 , vol. 45, # 3 p. 685 - 695 |
|
~%
274925-86-9 |
| Literature: Learmonth, David A.; Vieira-Coelho, Maria A.; Benes, Jan; Alves, Paula C.; Borges, Nuno; Freitas, Ana P.; Soares-da-Silva, Patricio Journal of Medicinal Chemistry, 2002 , vol. 45, # 3 p. 685 - 695 |
|
~%
274925-86-9 |
| Literature: Learmonth, David A.; Vieira-Coelho, Maria A.; Benes, Jan; Alves, Paula C.; Borges, Nuno; Freitas, Ana P.; Soares-da-Silva, Patricio Journal of Medicinal Chemistry, 2002 , vol. 45, # 3 p. 685 - 695 |
|
~%
274925-86-9 |
| Literature: Learmonth, David A.; Vieira-Coelho, Maria A.; Benes, Jan; Alves, Paula C.; Borges, Nuno; Freitas, Ana P.; Soares-da-Silva, Patricio Journal of Medicinal Chemistry, 2002 , vol. 45, # 3 p. 685 - 695 |
|
~%
274925-86-9 |
| Literature: Learmonth, David A.; Alves, Paula C. Synthetic Communications, 2002 , vol. 32, # 4 p. 641 - 649 |
| Precursor 7 | |
|---|---|
| DownStream 0 | |