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Nebicapone

Names

[ CAS No. ]:
274925-86-9

[ Name ]:
Nebicapone

[Synonym ]:
1-(3,4-dihydroxy-5-nitrophenyl)-2-phenyl-ethanone
1-(3,4-dihydroxy-5-nitrophenyl)-2-phenyl-1-ethanone
Nebicapone
UNII-NM2KXJ990T
BIA 3-202

Biological Activity

[Description]:

Nebicapone (BIA 3-202), a reversible catechol-O-methyltransferase (COMT) inhibitor, is mainly metabolized by glucuronidation. Nebicapone is mainly peripherally acting inhibitor that decreases the biotransformation of L-DOPA to 3-O-methyl-DOPA by inhibition of COMT, and it is potential for the treatment of Parkinson's disease.[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> COMT
Research Areas >> Metabolic Disease
Signaling Pathways >> Metabolic Enzyme/Protease >> COMT

[References]

[1]. Loureiro AI, et al. Human metabolism of nebicapone (BIA 3-202), a novel catechol-o-methyltransferase inhibitor: characterization of in vitro glucuronidation. Drug Metab Dispos. 2006 Nov;34(11):1856-62.

Chemical & Physical Properties

[ Molecular Formula ]:
C14H11NO5

[ Molecular Weight ]:
273.24100

[ Exact Mass ]:
273.06400

[ PSA ]:
103.35000

[ LogP ]:
2.95460

Safety Information

[ Hazard Codes ]:
Xi

Synthetic Route

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Precursor & DownStream

Precursor

DownStream