TREM2 agonist-2

Modify Date: 2025-08-25 16:45:18

TREM2 agonist-2 structure	Common Name	TREM2 agonist-2
	CAS Number	2738485-98-6	Molecular Weight	451.92
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₄H₂₃ClFN₅O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of TREM2 agonist-2

TREM2 agonist-2 (I-192) is an orally active triggering receptor expressed on myeloid cells 2 (TREM2) agonist (EC50<0.05 μM)[1].

Name	TREM2 agonist-2

Description	TREM2 agonist-2 (I-192) is an orally active triggering receptor expressed on myeloid cells 2 (TREM2) agonist (EC50<0.05 μM)[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
In Vitro	TREM2 agonist-2 (0-100 μM; 16 h) treatment activates hTREM2 in HEK293 cell[1]. Cell Viability Assay[1] Cell Line: HEK293 cells Concentration: 0-100 μM Incubation Time: 16 hours Result: Showed an EC50 value <0.05 μM.
In Vivo	TREM2 agonist-2 (oral gavage; 50 mg/kg; twice daily; one day) finds TREM2 target engagement on microglia[1]. Animal Model: Transgenic mice knock-in hTREM2-CV[1] Dosage: 50 mg/kg Administration: Oral gavage; 50 mg/kg; twice daily; one day Result: Increased genes associated with the adaptive immune response, innate immune response, microglia function, cytokine signalling, and cell cycle in hippocampus from animals.
References	[1]. Lara C. CZABANIUK, et al. Heterocyclic compounds as triggering receptor expressed on myeloid cells 2 agonists and methods of use. WO2021226629A1.

Molecular Formula	C₂₄H₂₃ClFN₅O
Molecular Weight	451.92

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: TREM2 agonist-2
Price: Check
Purity: 98.72%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Get all suppliers and price by the below link:

TREM2 agonist-2 suppliers

TREM2 agonist-2 price