Paradol

Modify Date: 2024-01-13 08:22:26

Paradol Structure
Paradol structure
Common Name Paradol
CAS Number 27113-22-0 Molecular Weight 278.387
Density 1.0±0.1 g/cm3 Boiling Point 406.5±30.0 °C at 760 mmHg
Molecular Formula C17H26O3 Melting Point N/A
MSDS N/A Flash Point 140.0±18.1 °C

 Use of Paradol


Paradol is a pungent phenolic substance found in ginger and other Zingiberaceae plants. Paradol is an effective inhibitor of tumor promotion in mouse skin carcinogenesis, binds to cyclooxygenase (COX)-2 active site.

 Names

Name 1-(4-hydroxy-3-methoxyphenyl)decan-3-one
Synonym More Synonyms

 Paradol Biological Activity

Description Paradol is a pungent phenolic substance found in ginger and other Zingiberaceae plants. Paradol is an effective inhibitor of tumor promotion in mouse skin carcinogenesis, binds to cyclooxygenase (COX)-2 active site.
Related Catalog
Target

COX-2

In Vitro Paradol ([6]-paradol) induces apoptosis in an oral squamous carcinoma cell line, KB, in a dose-dependent manner. Paradol induces apoptosis through a caspase-3-dependent mechanism[2].
In Vivo Administration of Paradol (6-paradol) (10 mg/kg) clearly reduces the number of Iba1-positive cells 1 and 3 days after the challenge. Moreover, Paradol dramatically reduces the number of Iba1-postive cells in periischemic regions even after 3 days following M/R challenge[3]. Paradol (6-paradol) exhibits the strongest anti-inflammatory effect of several paradol compounds in lipopolysaccharide-stimulated BV2 microglia derived from a mouse brain, including 2-, 4-, 6-, 8-, and 10-paradol. Furthermore, Paradol shows the strongest pungency of all of the known paradol analogues. Paradol also shows the highest contact time at the antiobesity site of action on the basis of the results shown for the absorption of the metabolites in this study[4].
Cell Assay KB, human oral epidermoid carcinoma cell lines (ATCC CCL-17) are plated at a density of 5×103 cells/200 μL/well into 96-well plate. After an overnight growth, the cells are treated with a series of paradol derivatives. All of the derivatives of paradol tested are dissolved in DMSO. The final concentration of DMSO in the culture medium is kept below 0.1% and the controls are treated with DMSO alone. Cell viability is assessed using MTT assay. In brief, after the cells are grown in the media in the absence or presence of the test compounds (e.g., Paradol, 10, 50, 100, 150, and 200 μM) for 48 h, they are then replaced to a 200 μL culture medium containing 0.5 mg/mL MTT for 3 h. The resulting MTT-formazan product is dissolved by an addition of the same volume of DMSO. The amount of formazan is determined by measuring the absorbance at 570 nm[2].
Animal Admin Mice[3] Male ICR mice (7 weeks old, 36±2 g) challenged with middle cerebral artery occlusion (MCAO)/reperfusion (M/R) are randomly divided into vehicle (10% Tween80)- or Paradol-administered groups (n=6~7 per group). Paradol dissolved in 10% Tween80 is orally administered (10 mg/kg) into mice at 1, 5, or 10 mg/kg immediately after reperfusion. Rats[4] Five-week-old Sprague-Dawley rats (male) are used. At 8 weeks of age, the rats are fasted for 14 h prior to the oral administration of olive oil (1 mL) containing zingerone or 6-, 8-, or 12-paradol (10 mg/kg). Three rats in each group are anesthetized with isoflurane, and samples (0.3 mL) of their blood are collected from their jugular vein using a heparinized needle and syringe at 0 (i.e., prior to the oral administration), 0.25, 0.5, 1, 3, 6, and 24 h after the oral administration of the olive oil containing test compounds. The AUC0-24h values determined using this time schedule are very similar compared with AUC0-24h that sampled the time points more minutely with other materials in our laboratory.
References

[1]. van Breemen RB, et al. Cyclooxygenase-2 inhibitors in ginger (Zingiber officinale). Fitoterapia. 2011 Jan;82(1):38-43.

[2]. Keum YS, et al. Induction of apoptosis and caspase-3 activation by chemopreventive [6]-paradol and structurally related compounds in KB cells. Cancer Lett. 2002 Mar 8;177(1):41-7.

[3]. Gaire BP, et al. Neuroprotective effect of 6-paradol in focal cerebral ischemia involves the attenuation of neuroinflammatory responses in activated microglia. PLoS One. 2015 Mar 19;10(3):e0120203.

[4]. Setoguchi S, et al. Pharmacokinetics of Paradol Analogues Orally Administered to Rats. J Agric Food Chem. 2016 Mar 9;64(9):1932-7.

 Chemical & Physical Properties

Density 1.0±0.1 g/cm3
Boiling Point 406.5±30.0 °C at 760 mmHg
Molecular Formula C17H26O3
Molecular Weight 278.387
Flash Point 140.0±18.1 °C
Exact Mass 278.188202
PSA 46.53000
LogP 3.83
Vapour Pressure 0.0±1.0 mmHg at 25°C
Index of Refraction 1.507
Storage condition -20°C

 Safety Information

HS Code 2914509090

 Synthetic Route

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Paradol Structure

Paradol

CAS#:27113-22-0

Literature: Locksley,H.D. et al. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1972 , p. 3001 - 3006

~%

Paradol Structure

Paradol

CAS#:27113-22-0

Literature: Locksley,H.D. et al. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1972 , p. 3001 - 3006

~%

Paradol Structure

Paradol

CAS#:27113-22-0

Literature: Locksley,H.D. et al. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1972 , p. 3001 - 3006

 Precursor & DownStream

Precursor  3

DownStream  0

 Customs

HS Code 2914509090
Summary HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

 Synonyms

[6]-Paradol
7V2R DQ CO1
EINECS 248-228-1
1-(4-hydroxy-3-methoxy-phenyl)-decan-3-one
3-Decanone,1-(4-hydroxy-3-methoxyphenyl)
5-Paradol
1-(4-Hydroxy-3-methoxyphenyl)-3-decanone
1-(4-hydroxy-3-methoxyphenyl)decan-5-one
1-(4-Hydroxy-3-methoxy-phenyl)-decan-3-on
6-Paradol
3-Decanone, 1-(4-hydroxy-3-methoxyphenyl)-
Paradol
Top Suppliers:I want be here
  • BioBioPha
  • China
  • Product Name: Paradol
  • Price: ¥900.0/5mg
  • Purity: 98.0%
  • Stocking Period: 1 Day
  • Contact: Xueping-Zheng

  • DC Chemicals Limited
  • China
  • Product Name: Paradol
  • Price: $500.0/100mg $1000.0/250mg $2000.0/1g
  • Purity: 98.0%
  • Stocking Period: 3 Day
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Price: $132/10mM*1mLinDMSO

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