Bcl-2-IN-4
Modify Date: 2025-09-18 19:45:11
Bcl-2-IN-4 structure
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Common Name | Bcl-2-IN-4 | ||
|---|---|---|---|---|
| CAS Number | 2703134-40-9 | Molecular Weight | 908.46 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C46H50ClN9O7S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Bcl-2-IN-4Bcl-2-IN-4 is a potent, orally active and selective Bcl-2 inhibitor with an IC50 of 1.5 nM. Bcl-2-IN-4 displays >200-fold selectivity over Bcl-xL (IC50 of 411 nM). Bcl-2-IN-4 inhibits RS4; 11 cell proliferation with an IC50 of 2.7 nM (WO2021180040A1; compound 2)[1]. |
| Name | Bcl-2-IN-4 |
|---|
| Description | Bcl-2-IN-4 is a potent, orally active and selective Bcl-2 inhibitor with an IC50 of 1.5 nM. Bcl-2-IN-4 displays >200-fold selectivity over Bcl-xL (IC50 of 411 nM). Bcl-2-IN-4 inhibits RS4; 11 cell proliferation with an IC50 of 2.7 nM (WO2021180040A1; compound 2)[1]. |
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| Related Catalog | |
| Target |
Bcl-2:1.5 nM (IC50) Bcl-xL:411 nM (IC50) |
| References |
[1]. Hongjian Wang, et al. Benzo five-membered cyclic compound. WO2021180040A1. |
| Molecular Formula | C46H50ClN9O7S |
|---|---|
| Molecular Weight | 908.46 |
| InChIKey | PFVMZVXYLOWBLC-UHFFFAOYSA-N |
| SMILES | CC1(C)CCC(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4cc([N+](=O)[O-])c(NCC5CCOCC5)c5[nH]cnc45)c(Oc4cnc5[nH]ccc5c4)c3)CC2)=C(c2ccc(Cl)cc2)C1 |